{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:24:59Z","timestamp":1768296299536,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T00:00:00Z","timestamp":1581638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>We report the case of a patient with metastatic castration\u2010resistant prostate cancer with microsatellite instability\u2010high who was treated with pembrolizumab after cabazitaxel administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 58\u2010year\u2010old patient with heavily pretreated metastatic castration\u2010resistant prostate cancer, whose prostate surgical specimen was disclosed as microsatellite instability\u2010high, underwent pembrolizumab therapy. After initiation of pembrolizumab, his prostate\u2010specific antigen level decreased, imaging findings showed good response with lymph node shrinkage, and his walking difficulty decreased dramatically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rarity of microsatellite instability\u2010high tumor in castration\u2010resistant prostate cancer may hamper pembrolizumab administration. This potentially active agent should be considered as part of a treatment regimen for patients with microsatellite instability\u2010high castration\u2010resistant prostate cancer. To the best of our knowledge, this is the first report of a Japanese castration\u2010resistant prostate cancer patient who demonstrated clinical benefit from pembrolizumab treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12144","type":"journal-article","created":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T06:01:07Z","timestamp":1581746467000},"page":"62-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pembrolizumab for a patient with metastatic castration\u2010resistant prostate cancer with microsatellite instability\u2010high"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9454-3345","authenticated-orcid":false,"given":"Motohiro","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Department of Urology Cancer Institute Hospital Japanese Foundation for Cancer Research Tokyo 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