{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:39:43Z","timestamp":1771051183073,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T00:00:00Z","timestamp":1624752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Apalutamide\u2010associated skin rash is a more common adverse event in the Japanese population than in the global population. However, its mechanism remains elusive, and limited histopathological information hampers further understanding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>Case 1: a 71\u2010year\u2010old man with metastatic castration\u2010sensitive prostate cancer developed a skin rash after 70\u00a0days of apalutamide treatment. Case 2: a 71\u2010year\u2010old man with non\u2010metastatic castration\u2010resistant prostate cancer developed a skin rash after 71\u00a0days of apalutamide treatment. In both cases, the skin rash presented as a slightly exudative erythema. The histology showed spongiosis of the epidermis and perivascular and interstitial infiltration of lymphocytes and eosinophils in the upper dermis without necrotic keratinocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Apalutamide\u2010induced skin rashes can involve an eczematous reaction clinically and histologically.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12331","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T04:03:00Z","timestamp":1624852980000},"page":"299-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Apalutamide\u2010associated skin rash in patients with prostate cancer: Histological evaluation by skin biopsy"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3884-8915","authenticated-orcid":false,"given":"Yoichiro","family":"Tohi","sequence":"first","affiliation":[{"name":"Department of 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