{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:21:58Z","timestamp":1761582118414,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K06914","18H02938"],"award-info":[{"award-number":["21K06914","18H02938"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Definitive diagnosis of translocation renal cell carcinoma is challenging. We herein experienced a case of translocation(6;11) renal cell carcinoma, successfully diagnosed by using fluorescence in\u00a0situ hybridization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>During the follow\u2010up of a 21\u2010year\u2010old man with Crohn's disease, computed tomography revealed a 40\u2010mm mass in the right kidney. Since imaging could not exclude malignancy, needle biopsy was performed. The histological diagnosis from the biopsy specimen was renal cell carcinoma, but histological typing had not been done adequately. A laparoscopic partial nephrectomy was then performed. Transcription factor EB immunoreactivity was positive, transcription factor EB rearrangement was shown by break apart and fusion fluorescence in\u00a0situ hybridization. As a result, a definitive diagnosis of t(6; 11) renal cell carcinoma was made. There has been no recurrence for 5\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transcription factor EB immunohistochemistry and fluorescence in\u00a0situ hybridization are useful diagnostic tools for renal tumors of young generation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12353","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T23:21:16Z","timestamp":1628810476000},"page":"375-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["t(6; 11) renal cell carcinoma. A case report successfully diagnosed by using fluorescence in situ hybridization"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9315-6650","authenticated-orcid":false,"given":"Hidekazu","family":"Nishizawa","sequence":"first","affiliation":[{"name":"Department of Urology Faculty of Life Sciences Kumamoto University Kumamoto City Japan"},{"name":"Laboratory of Cancer Metabolism International Research Center for Medical Sciences (IRCMS) Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-6683","authenticated-orcid":false,"given":"Masaya","family":"Baba","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Metabolism International Research Center for Medical Sciences (IRCMS) Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6220-8179","authenticated-orcid":false,"given":"Mitsuko","family":"Furuya","sequence":"additional","affiliation":[{"name":"Pathology Center GeneticLab Co., Ltd Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7731-9509","authenticated-orcid":false,"given":"Ikuma","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Yokohama City University Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6972-8065","authenticated-orcid":false,"given":"Ryoma","family":"Kurahashi","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Life Sciences Kumamoto University Kumamoto City 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