{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:14:39Z","timestamp":1747149279489,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The combination of pembrolizumab and axitinib has recently been approved as a first\u2010line treatment for previously untreated metastatic renal cell carcinoma. However, immune\u2010related adverse events are not well known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 65\u2010year\u2010old male was diagnosed with renal cell carcinoma with metastases to the brain and lungs. The patient had a medical history of stasis dermatitis. During the combined treatment of pembrolizumab and axitinib, blisters appeared on the lower extremities. Skin biopsy revealed septal panniculitis, pustules, and perivascular lymphocytic and neutrophilic infiltration of the skin, and the patient was diagnosed with immune\u2010related dermatitis. The dermatitis improved with oral prednisolone treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A case of immune\u2010related dermatitis during combinatorial treatment with pembrolizumab and axitinib for renal cell carcinoma has been reported. Preexisting stasis dermatitis may have affected the onset and deterioration of immune\u2010related dermatitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12356","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T01:52:13Z","timestamp":1628214733000},"page":"386-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immune\u2010related dermatitis during combined treatment with pembrolizumab and axitinib in a patient with metastatic renal cell\\x92carcinoma with stasis dermatitis"],"prefix":"10.1002","volume":"4","author":[{"given":"Shunsuke","family":"Imai","sequence":"first","affiliation":[{"name":"Urology NTT Medical Center Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7473-3325","authenticated-orcid":false,"given":"Masaki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Urology NTT Medical 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