{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:09:46Z","timestamp":1753888186598,"version":"3.40.5"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Immune checkpoint inhibitors are one of the standard treatments for metastatic renal cell carcinoma. Among immune\u2010related adverse events, the sarcoidosis\u2010like reaction is frequently difficult to differentiate from cancer progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 58\u2010year\u2010old man with renal cell carcinoma with multiple lung metastases was treated with ipilimumab and nivolumab after nephrectomy. Computed tomography after three courses of treatment revealed hilar\/mediastinal lymphadenopathies, pleural nodules, and pulmonary interstitial lesions, whereas lung metastases were markedly regressed. Considering positive findings of Gallium scintigraphy and serological tests together, we clinically judged the new lesions as a sarcoidosis\u2010like reaction and continued the treatment until cessation by liver dysfunction. After discontinuation of the immunotherapy, the sarcoidosis\u2010like reaction was regressed without cancer relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report here the first case of a clinically diagnosed sarcoidosis\u2010like reaction in metastatic renal cell carcinoma following treatment with immune checkpoint inhibitors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12372","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T09:55:02Z","timestamp":1632477302000},"page":"15-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A case of sarcoidosis\u2010like reaction associated with immune checkpoint inhibitors in metastatic renal cell carcinoma"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8057-1177","authenticated-orcid":false,"given":"Akiyoshi","family":"Katagiri","sequence":"first","affiliation":[{"name":"Department of Urology Niigata Prefectural Central Hospital Joetsu Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Urology Niigata Prefectural Central Hospital Joetsu Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Urology Niigata Prefectural Central Hospital Joetsu Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.05.032"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0102"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.04.031"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.02.024"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00141212"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.v18i1.647"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01443"}],"container-title":["IJU Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iju5.12372","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:17:42Z","timestamp":1693207062000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iju5.12372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,24]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/iju5.12372"],"URL":"https:\/\/doi.org\/10.1002\/iju5.12372","archive":["Portico"],"relation":{},"ISSN":["2577-171X","2577-171X"],"issn-type":[{"type":"print","value":"2577-171X"},{"type":"electronic","value":"2577-171X"}],"subject":[],"published":{"date-parts":[[2021,9,24]]},"assertion":[{"value":"2021-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}