{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:14:43Z","timestamp":1747149283715,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Mucin\u2010producing adenocarcinoma of the prostate is a rare disease that includes prostate adenocarcinoma with mucus production, secondary adenocarcinoma from the bladder or colorectum, and adenocarcinoma from the urothelium of the prostatic urethra. We describe prostate\u2010specific antigen\u2010negative mucin\u2010producing urothelial\u2010type adenocarcinoma of the prostate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>The patient had urinary retention and a serum prostate\u2010specific antigen level of 0.74\u2009ng\/mL. Computed tomography and magnetic resonance imaging revealed a prostate tumor with a mucous component. We diagnosed adenocarcinoma by prostate biopsy and subsequently performed robot\u2010assisted radical prostatectomy. Mucin\u2010producing urothelial\u2010type adenocarcinoma of the prostate was diagnosed by pathological examinations. Lung metastasis, developing within 3\u2009months after surgery, was treated using chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Endocrine therapy is ineffective for mucin\u2010producing urothelial\u2010type adenocarcinoma of the prostate. Mucin\u2010producing urothelial\u2010type adenocarcinoma of the prostate diagnosis requires pathological and immunohistochemical analyses. It is important to surgically remove the primary lesion, and robot\u2010assisted radical prostatectomy may provide an effective approach. Multimodal therapy is essential to treat for mucin\u2010producing urothelial\u2010type adenocarcinoma of the prostate.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12380","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T07:34:48Z","timestamp":1632555288000},"page":"32-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mucin\u2010producing urothelial\u2010type adenocarcinoma of the prostate diagnosed after robot\u2010assisted radical prostatectomy"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2892-3750","authenticated-orcid":false,"given":"Kosuke","family":"Shimizu","sequence":"first","affiliation":[{"name":"Departments of Urology Graduate School of Medicine Yamaguchi University Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8420-0370","authenticated-orcid":false,"given":"Ryo","family":"Inoue","sequence":"additional","affiliation":[{"name":"Departments of Urology Graduate School of Medicine Yamaguchi University Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Tomochika","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Breast and Endocrine Surgery Graduate School of Medicine Yamaguchi University Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohito","family":"Isoyama","sequence":"additional","affiliation":[{"name":"Departments of Urology Graduate School of Medicine Yamaguchi University Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Departments of Urology Graduate School of Medicine Yamaguchi University Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0568-1258","authenticated-orcid":false,"given":"Hiroaki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Departments of Urology Graduate School of Medicine Yamaguchi University Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Departments of Urology Graduate School of Medicine Yamaguchi University Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigefumi","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Departments of Surgery Kanmon Medical Center Shimonoseki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-4366","authenticated-orcid":false,"given":"Toyonori","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology School of Medicine Aichi Medical University Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5607-7769","authenticated-orcid":false,"given":"Hideyasu","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Departments of Urology Graduate School of Medicine Yamaguchi University Ube Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181589f72"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896911414272"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31802ff7c4"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.132"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e318271a361"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2018.11.005"},{"key":"e_1_2_12_8_1","first-page":"647","article-title":"Mucin\u2010producing urothelial type prostatic adenocarcinoma with signet ring cells and increased Ca 19.9 and Cea. Case report and literature review","volume":"72","author":"Ca\u00f1o\u2010Velasco J","year":"2019","journal-title":"Arch. Esp. Urol."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590310025532"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800317"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-55382006000600009"},{"key":"e_1_2_12_12_1","first-page":"184","article-title":"Co\u2010existence of mucin\u2010producing urothelial\u2010type adenocarcinoma of the prostate and inverted papilloma of the bladder","volume":"21","author":"Mu XN","year":"2017","journal-title":"Contemp. 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