{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:14:50Z","timestamp":1747149290420,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Small cell carcinoma of the prostate has a poor prognosis even with standard systemic chemotherapy. We report a case, in which combination therapy with radiation and hyperthermia\u2010induced clinical complete response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>An 87\u2010year\u2010old man complaining of dysuria was referred to our hospital. Based on magnetic resonance imaging findings and a history of prostate cancer, a prostate biopsy was performed, and small cell carcinoma of the prostate was diagnosed. Whole\u2010pelvis radiation therapy was administered with an additional dose to the prostate; eight cycles of hyperthermia treatment (8\u2009MHz radiofrequency capacitive regional hyperthermia) were administered concurrently. Normalized neuron\u2010specific enolase levels and magnetic resonance imaging confirmed a complete response. A few cancer cells were seen in the post\u2010treatment biopsy specimen, which demonstrated positive immunostaining for heat shock protein 70 and HIKESHI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this case, small cell carcinoma of the prostate was effectively treated with combined radiation and hyperthermia therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12413","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T07:19:00Z","timestamp":1642231140000},"page":"113-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Combination therapy with radiation and hyperthermia\u2010induced clinical complete response of small cell carcinoma of prostate"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2257-3892","authenticated-orcid":false,"given":"Noriyasu","family":"Kawai","sequence":"first","affiliation":[{"name":"Department of Nephro\u2010urology Graduate School of Medical Sciences Nagoya City University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Graduate School of Medical Sciences Nagoya City University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Naiki\u2010Ito","sequence":"additional","affiliation":[{"name":"Department of Experimental Pathology and Tumor Biology Graduate School of Medical Sciences Nagoya City University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keitaro","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Graduate School of Medical Sciences Nagoya City University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Etani","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Graduate School of Medical Sciences Nagoya City University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7638-6048","authenticated-orcid":false,"given":"Taku","family":"Naiki","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Graduate School of Medical Sciences Nagoya City University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9968-7468","authenticated-orcid":false,"given":"Shuzo","family":"Hamamoto","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Graduate School of Medical Sciences Nagoya City University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2080-3794","authenticated-orcid":false,"given":"Atsushi","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Graduate School of Medical Sciences Nagoya City University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Murai","sequence":"additional","affiliation":[{"name":"Department of Radiology Graduate School of Medical Sciences Nagoya City University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-2477","authenticated-orcid":false,"given":"Takahiro","family":"Yasui","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Graduate School of Medical Sciences Nagoya City University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.21"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2006.10.026"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3791"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656730600799873"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656730701658234"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2012.695428"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2013.829247"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2016.1213430"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02059-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2019.1665718"},{"key":"e_1_2_11_12_1","first-page":"600","article-title":"Definitive radiotherapy plus regional hyperthermia for high\u2010risk and very high\u2010risk prostate carcinoma: Thermal parameters correlated with biochemical relapse\u2010free survival","volume":"31","author":"Yahara K","year":"2015","journal-title":"Int. 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