{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:56:57Z","timestamp":1761649017110,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Recent introduction of immuno\u2010oncology drugs such as pembrolizumab has resulted in improved outcomes for urothelial carcinoma patients. However, immune\u2010related adverse events generally show great variance and are often difficult to diagnose and control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>An 84\u2010year\u2010old Japanese male with urothelial carcinoma metastasis to the lungs after a laparoscopic left radical nephroureterectomy procedure was treated with pembrolizumab, an immuno\u2010oncology drug, as second\u2010line therapy. At week 6, inflammatory arthralgia involving the hands and shoulder joints, and edema of the hands were presented. The diagnosis was remitting seronegative symmetrical synovitis with pitting edema syndrome. Pembrolizumab was discontinued, and oral corticosteroid therapy was started. Two months later, pembrolizumab treatment was resumed because of a significant improvement in patient condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although rare, immune\u2010related adverse events are occasionally encountered during the use of immune\u2010oncology drugs; thus, early diagnosis and appropriate treatment are important.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12426","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T07:39:59Z","timestamp":1651563599000},"page":"219-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Remitting seronegative symmetrical synovitis with pitting edema syndrome induced by pembrolizumab in patient with urothelial carcinoma"],"prefix":"10.1002","volume":"5","author":[{"given":"Akihiro","family":"Yoshimura","sequence":"first","affiliation":[{"name":"Department of Urology Hyogo Prefectural Nishinomiya Hospital Nishinomiya City Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8581-2427","authenticated-orcid":false,"given":"Kazuaki","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Nishinomiya Hospital Nishinomiya City Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei","family":"Tadokoro","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Hyogo Prefectural Nishinomiya Hospital  Nishinomiya City Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teppei","family":"Wakita","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Nishinomiya Hospital Nishinomiya City Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Fukae","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Nishinomiya Hospital Nishinomiya City Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Nishinomiya Hospital Nishinomiya City Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Hyogo Prefectural Nishinomiya Hospital  Nishinomiya City Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidefumi","family":"Kishikawa","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Nishinomiya Hospital Nishinomiya City Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1985.03360190069027"},{"issue":"20","key":"e_1_2_12_3_1","first-page":"30","article-title":"RS3PE syndrome: an overview","volume":"18","author":"Olivieri I","year":"2000","journal-title":"Clin. 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