{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:13:15Z","timestamp":1787238795520,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Methotrexate\u2010associated lymphoproliferative disorders appear during treatment with methotrexate as an immunosuppressive drug. However, the mechanism and frequency are still unknown, and the treatment is undefined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 76\u2010year\u2010old woman was admitted to the hospital with back pain, and magnetic resonance imaging showed a tumor in the right adrenal region. She had received methotrexate for rheumatoid arthritis. Enhanced computed tomography showed a tumor of 90\u2009mm in diameter on the dorsal side of the liver abutting to the inferior vena cava. The preoperative diagnosis was a hepatic invasion of right adrenocortical carcinoma and right adrenalectomy was performed. The histopathological diagnosis was diffuse large B\u2010cell lymphoma. The final diagnosis was methotrexate\u2010associated lymphoproliferative disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>It is important to consider methotrexate\u2010associated lymphoproliferative disorders before surgery when neoplastic lesions are found in patients taking methotrexate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.12429","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T01:54:55Z","timestamp":1646790895000},"page":"172-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Epstein\u2010Barr virus\u2010related diffuse large B\u2010cell lymphoma type methotrexate\u2010associated lymphoproliferative disorders presenting in the adrenal gland"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6983-1935","authenticated-orcid":false,"given":"Kazuki","family":"Doi","sequence":"first","affiliation":[{"name":"Department of Urology Hyogo Prefectural Amagasaki General Medical Center Amagasaki\u2010shi Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mototsugu","family":"Muramaki","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Amagasaki General Medical Center Amagasaki\u2010shi Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Pathology Hyogo Prefectural Amagasaki General Medical Center  Amagasaki\u2010shi Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Katsura","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Amagasaki General Medical Center Amagasaki\u2010shi Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6111-0305","authenticated-orcid":false,"given":"Hiroyuki","family":"Fukunaga","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Amagasaki General Medical Center Amagasaki\u2010shi Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Amagasaki General Medical Center Amagasaki\u2010shi Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minori","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Amagasaki General Medical Center Amagasaki\u2010shi Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Amagasaki General Medical Center Amagasaki\u2010shi Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"1741","article-title":"Lymphoma developing in a patient with rheumatoid arthritis taking low dose weekly methotrexate","volume":"18","author":"Ellman MH","year":"1991","journal-title":"J. Rheumatol."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.02.029"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21003"},{"key":"e_1_2_12_5_1","first-page":"498","article-title":"Methotrexate (MTX)\u2010associated lymphoproliferative disorder","volume":"28","author":"Suzuki Y","year":"2002","journal-title":"Rheumatology"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001809"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001270"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3143\/geriatrics.54.567"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21675"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140533"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22306"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.1996.0397"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/v9110339"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1812-3"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1369073"}],"container-title":["IJU Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iju5.12429","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T07:06:34Z","timestamp":1692947194000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iju5.12429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,8]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/iju5.12429"],"URL":"https:\/\/doi.org\/10.1002\/iju5.12429","archive":["Portico"],"relation":{},"ISSN":["2577-171X","2577-171X"],"issn-type":[{"value":"2577-171X","type":"print"},{"value":"2577-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,8]]},"assertion":[{"value":"2021-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}