{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:43:58Z","timestamp":1792622638309,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Recently, an absorbable hydrogel spacer is becoming more widespread to reduce rectal radiation dose for radiation therapy for localized prostate cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 79\u2010year\u2010old male patient was referred to our hospital for radical treatment of organ\u2010confined prostate cancer. Low\u2010dose\u2010rate brachytherapy was performed, and the hydrogel spacer injection was added. The spacer was properly injected between the prostate and the rectum, causing no acute complications during hospitalization. Two months after low\u2010dose\u2010rate brachytherapy, the patient visited our hospital with constipation and melena, without fever. He was diagnosed with ischemic proctitis based on clinical courses and examinations. He was hospitalized for 19\u2009days and made a complete recovery with conservative treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Herein, we report the first case of ischemic proctitis after low\u2010dose\u2010rate brachytherapy using hydrogel spacer for prostate cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12444","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T07:40:02Z","timestamp":1649749202000},"page":"237-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ischemic proctitis after low\u2010dose\u2010rate brachytherapy using hydrogel spacer for prostate cancer"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-8524","authenticated-orcid":false,"given":"Ren","family":"Toriumi","sequence":"first","affiliation":[{"name":"Departments of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-8834","authenticated-orcid":false,"given":"Hiroshi","family":"Yaegashi","sequence":"additional","affiliation":[{"name":"Departments of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Departments of Radiology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Departments of Radiology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Shigehara","sequence":"additional","affiliation":[{"name":"Departments of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Izumi","sequence":"additional","affiliation":[{"name":"Departments of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Kadono","sequence":"additional","affiliation":[{"name":"Departments of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Mizokami","sequence":"additional","affiliation":[{"name":"Departments of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.01.078"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.01.005"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2011.08.003"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2014.06.008"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3565-1"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-018-1309-0"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14123"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.04.030"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2020.09.018"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-020-03414-6"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-020-00791-1"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i8.1236"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.14237"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.7302"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-206931"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.03.020"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5163-8"},{"key":"e_1_2_13_19_1","first-page":"e74","article-title":"SpaceOAR hydrogel spacer for reducing radiation toxicity during radiotherapy for prostate cancer","volume":"156","author":"Armstrong N","year":"2021","journal-title":"A systematic review. 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