{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T12:24:14Z","timestamp":1775651054182,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T00:00:00Z","timestamp":1649548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>We report a prostate cancer case diagnosed during leuprorelin treatment for spinal and bulbar muscular atrophy which is a X\u2010linked recessive, lower motor neuron disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 64\u2010year\u2010old man who had received leuprorelin treatment over 3\u2009years for his spinal and bulbar muscular atrophy presented with an enlarged prostate accompanied by abdominal pain and constipation. An abnormally high serum prostate\u2010specific antigen of 17.7\u2009ng\/mL and a low (castration level) serum testosterone level of 0.23\u2009ng\/mL were measured. Prostate needle biopsy revealed adenocarcinoma of the prostate. Orchiectomy, darolutamide, and radiation therapy for the prostate were initiated, resulting in a favorable response which was maintained at 12\u2009months of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prostate cancer can occur even when leuprorelin is used for spinal and bulbar muscular atrophy; therefore, checking serum prostate\u2010specific antigen to screen for prostate cancer before leuprorelin administration should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12447","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T02:28:57Z","timestamp":1649644137000},"page":"251-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Castration\u2010resistant prostate cancer diagnosed during leuprorelin treatment for spinal and bulbar muscular atrophy"],"prefix":"10.1002","volume":"5","author":[{"given":"Atsuhi","family":"Yanase","sequence":"first","affiliation":[{"name":"Department of Urology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0901-3209","authenticated-orcid":false,"given":"Toru","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Department of Urology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6966-5874","authenticated-orcid":false,"given":"Takahiro","family":"Akimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Urology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0069-7392","authenticated-orcid":false,"given":"Jun","family":"Kamei","sequence":"additional","affiliation":[{"name":"Department of Urology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Fujisaki","sequence":"additional","affiliation":[{"name":"Department of Urology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Urology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tameto","family":"Naoi","sequence":"additional","affiliation":[{"name":"Rehabilitation Center Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuya","family":"Morita","sequence":"additional","affiliation":[{"name":"Rehabilitation Center Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Department of Urology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005344403603"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70182-4"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09251-x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.11.3777"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.15.3181"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14595"},{"key":"e_1_2_13_8_1","first-page":"1937","article-title":"The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer","volume":"55","author":"Irvine RA","year":"1995","journal-title":"Cancer Res."},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690746"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68604-1"},{"key":"e_1_2_13_11_1","first-page":"814","article-title":"[A case of prostate cancer associated with globospinal muscular atrophy] (in Japanese, conference proceedings)","volume":"15","author":"Yoshida M","year":"2002","journal-title":"Jpn. J. Urol. Surg."},{"key":"e_1_2_13_12_1","first-page":"S296","article-title":"[A case of spinal and bulbar muscular atrophy in which the choice of anesthesia method affected the possibility of early extubation] (in Japanese, conference proceedings)","volume":"31","author":"Sugahara F","year":"2011","journal-title":"J. Jpn. Soc. Clin. Anesth."},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.111.013698"},{"key":"e_1_2_13_14_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4103\/aja.aja_37_21","article-title":"Germline BRCA2 mutation in a case of aggressive prostate cancer accompanied by spinal bulbar muscular atrophy","volume":"24","author":"Hongo H","year":"2021","journal-title":"Asian J. Androl."},{"key":"e_1_2_13_15_1","first-page":"PO.18.00115","article-title":"BRCA2\u2010associated prostate cancer in a patient with spinal and bulbar muscular atrophy","volume":"2","author":"Conteduca V","year":"2018","journal-title":"JCO Precis. Oncol."},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz124"}],"container-title":["IJU Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iju5.12447","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T22:19:08Z","timestamp":1726957148000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iju5.12447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,10]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/iju5.12447"],"URL":"https:\/\/doi.org\/10.1002\/iju5.12447","archive":["Portico"],"relation":{},"ISSN":["2577-171X","2577-171X"],"issn-type":[{"value":"2577-171X","type":"print"},{"value":"2577-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,10]]},"assertion":[{"value":"2022-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}