{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:15:03Z","timestamp":1747149303323,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Recent studies have indicated an improvement in the survival rate of patients using docetaxel in addition to androgen deprivation therapy for high\u2010volume metastatic hormone\u2010sensitive prostate cancer. Hepatorrhexis, characterized by the rupture of the liver, is a rare complication associated with chemotherapies. We report a case of hepatic metastases rupture during androgen deprivation therapy combined with upfront docetaxel chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 77\u2010year\u2010old man diagnosed with high\u2010volume metastatic hormone\u2010sensitive prostate cancer received an upfront docetaxel treatment combined with androgen deprivation therapy. Hepatic metastases rupture with substantial hemoperitoneum occurred on the 14th day of the fifth cycle of docetaxel chemotherapy. Transcatheter arterial embolization was performed; however, despite receiving optimal supportive care, the patient died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The addition of upfront docetaxel to androgen deprivation therapy may be effective in patients with high\u2010volume metastatic hormone\u2010sensitive prostate cancer; however, strict observation is required to monitor for the occurrence of rare complications, including hepatorrhexis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12512","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T05:54:42Z","timestamp":1658987682000},"page":"451-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rupture of liver metastasis in <scp>high\u2010volume<\/scp> metastatic prostate cancer patient on androgen deprivation therapy combined with upfront docetaxel chemotherapy"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-7354","authenticated-orcid":false,"given":"Kenichi","family":"Hata","sequence":"first","affiliation":[{"name":"Department of Urology Atsugi City Hospital  Atsugi City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Urology Atsugi City Hospital  Atsugi City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Urology Atsugi City Hospital  Atsugi City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5673-1553","authenticated-orcid":false,"given":"Takahiro","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Urology Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.22.4.232"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-03963-y"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70560-0"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503747"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01037-5"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001375"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283293d27"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000530"},{"key":"e_1_2_12_10_1","first-page":"001142","article-title":"Haemoperitoneum due to spontaneous rupture of a liver metastasis","volume":"6","author":"Dolapsakis C","year":"2019","journal-title":"Eur. 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