{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T21:03:28Z","timestamp":1747947808776,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients with multiple endocrine neoplasia type 2A (MEN2A) harboring a pathological variant in the RET gene are characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, and hyperparathyroidism. Although pheochromocytoma is currently defined as a malignant tumor, MEN2A\u2010associated pheochromocytoma is known to have a small risk of metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>The case was a 62\u2010year\u2010old Japanese male with bilateral pheochromocytoma, multiple metastases in the liver and bones, and a cardiac thrombus. Genetic testing revealed a pathological variant at codon 634 of the RET gene, thereby leading a diagnosis of MTC. We considered that the multiple metastases were due to MTC; however, a liver biopsy revealed metastasis of pheochromocytoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When pheochromocytoma precedes MTC, the diagnosis of MEN2A may be difficult.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12514","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T08:43:29Z","timestamp":1662453809000},"page":"459-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Progressive metastatic pheochromocytoma induced by multiple endocrine neoplasia type <scp>2A<\/scp> with a lethal outcome"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3952-5643","authenticated-orcid":false,"given":"Koshiro","family":"Nishimoto","sequence":"first","affiliation":[{"name":"Department of Uro\u2010Oncology Saitama Medical University International Medical 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