{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:56:54Z","timestamp":1793908614450,"version":"4.8.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Small\u2010cell carcinoma of the prostate has a poor prognosis, and treatment options for the refractory disease are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 68\u2010year\u2010old man with prostate cancer was referred to our hospital. He was treated with combined androgen blockade (bicalutamide and degarelix acetate). The disease progressed to castration\u2010resistant prostate cancer, but with additional treatment, prostate\u2010specific antigen levels remained below 0.02\u2009ng\/mL. However, computed tomography revealed enlarged right inguinal lymph nodes; moreover, his neuron\u2010specific enolase levels were elevated. Histopathologic analysis of a biopsied lymph node confirmed small\u2010cell carcinoma. After administering cytotoxic chemotherapy (etoposide plus cisplatin and amrubicin), the patient temporarily improved before relapsing. After genetic testing of the biopsy specimen revealed a<jats:italic>BRCA2<\/jats:italic>deletion, we administered the oral PARP\u20102 inhibitor olaparib, which has achieved partial remission for 8\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PARP\u20102 inhibition may improve the survival of patients with<jats:italic>BRCA2<\/jats:italic>\u2010positive small\u2010cell carcinoma of the prostate.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12523","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T06:18:35Z","timestamp":1660371515000},"page":"489-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prostate cancer recurring as small\u2010cell carcinoma with a<scp><i>BRCA2<\/i><\/scp>somatic mutation"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3944-6280","authenticated-orcid":false,"given":"Ryo","family":"Yabusaki","sequence":"first","affiliation":[{"name":"Department of Urology Shizuoka General Hospital Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6342-7691","authenticated-orcid":false,"given":"Koji","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Urology Shizuoka General Hospital Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisei","family":"Taku","sequence":"additional","affiliation":[{"name":"Department of Oncology Shizuoka General Hospital Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pathology Shizuoka General Hospital Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06177-2"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-020-01003-9"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506859"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318058a96b"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00006"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-18-0226"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.3553"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.231068"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-019-0678-6"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3791"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1809064"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30098-5"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.146"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.383"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1701695"},{"key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.17.00029","article-title":"Prospective genomic profiling of prostate cancer across disease states reveals germline and somatic alterations that may affect clinical decision making","volume":"2017","author":"Abida W","year":"2017","journal-title":"JCO Precis. Oncol."},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.1882"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/mcs.a005801"}],"container-title":["IJU Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iju5.12523","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T17:09:47Z","timestamp":1727802587000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iju5.12523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,12]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/iju5.12523"],"URL":"https:\/\/doi.org\/10.1002\/iju5.12523","archive":["Portico"],"relation":{},"ISSN":["2577-171X","2577-171X"],"issn-type":[{"value":"2577-171X","type":"print"},{"value":"2577-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,12]]},"assertion":[{"value":"2022-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}