{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:15:04Z","timestamp":1747149304967,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Leptomeningeal carcinomatosis in small cell carcinoma of the prostate is rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 69\u2010year\u2010old man visited our hospital due to dysuria and edema. Bilateral hydronephrosis and lymph node metastases due to a pelvic tumor were observed. Although the prostate\u2010specific antigen level was normal, the tumor was suspected to originate from the prostate. He underwent percutaneous nephrostomy and prostate biopsy. Histopathology revealed small cell carcinoma accompanied by increased pro\u2010gastrin\u2010releasing peptide and neuron\u2010specific enolase levels. After receiving systemic chemotherapy with carboplatin and etoposide and radiation therapy for prostate, these lesions gradually decreased in size, and tumor markers normalized. Ten months after the initial diagnosis, he developed consciousness disorder and seizure. Magnetic resonance imaging revealed leptomeningeal carcinomatosis without any other recurrences and elevated tumor markers. He died 4\u2009weeks after these symptoms appeared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Careful monitoring of the central nervous system should be considered in small cell carcinoma of the prostate patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12524","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T08:19:24Z","timestamp":1660205964000},"page":"493-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Leptomeningeal carcinomatosis in small cell carcinoma of the prostate"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6204-0866","authenticated-orcid":false,"given":"Kyotaro","family":"Fukuta","sequence":"first","affiliation":[{"name":"Department of Urology Tokushima Prefectural Central Hospital  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keito","family":"Shiozaki","sequence":"additional","affiliation":[{"name":"Department of Urology Tokushima Prefectural Central Hospital  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Urology Tokushima Prefectural Central Hospital  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Izaki","sequence":"additional","affiliation":[{"name":"Department of Urology Tokushima Prefectural Central Hospital  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokushima Prefectural Central Hospital  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Fukawa","sequence":"additional","affiliation":[{"name":"Department of Urology Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihisa","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Urology Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyo","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Urology Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiro\u2010omi","family":"Kanayama","sequence":"additional","affiliation":[{"name":"Department of Urology Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.5409"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.12.065"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37427-X"},{"key":"e_1_2_12_5_1","first-page":"80","article-title":"Leptomeningeal carcinomatosis of prostate cancer: a case report and review of the literature","volume":"22","author":"Neeman E","year":"2020","journal-title":"Rev. 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