{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:39:24Z","timestamp":1792172364068,"version":"4.4.0"},"reference-count":7,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T00:00:00Z","timestamp":1663977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Immune checkpoint inhibitors are widely used in various cancers as a standard treatment. However, while various immune\u2010related adverse events related to immune checkpoint inhibitors have been reported, there are few reports of lower urinary tract symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>The patient was a 60\u2010year\u2010old man with primary lung cancer who was receiving long\u2010term nivolumab therapy. He was referred to our department due to the sudden onset of glans penile pain and micturition pain. We suspected non\u2010bacterial cystitis as an immune\u2010related adverse event caused by nivolumab and were able to treat it by administering prednisolone. While his symptoms and findings on cystoscopy recurred during prednisolone therapy, we were able to treat him again by administering an additional dose of infliximab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A few reports have described cases of immune checkpoint inhibitor\u2010induced cystitis for which prednisolone was effective. This report is the first to describe cystitis as a steroid\u2010resistant immune\u2010related adverse event.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12532","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T07:40:31Z","timestamp":1664005231000},"page":"521-523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A case of steroid\u2010resistant cystitis as an immune\u2010related adverse event during treatment with nivolumab for lung cancer, which was successfully treated with infliximab"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6111-0305","authenticated-orcid":false,"given":"Hiroyuki","family":"Fukunaga","sequence":"first","affiliation":[{"name":"Department of Urology Kansai Rosai Hospital  Amagasaki\u2010shi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Sumii","sequence":"additional","affiliation":[{"name":"Department of Urology Kansai Rosai Hospital  Amagasaki\u2010shi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Urology Kansai Rosai Hospital  Amagasaki\u2010shi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Okuno","sequence":"additional","affiliation":[{"name":"Department of Urology Kansai Rosai Hospital  Amagasaki\u2010shi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Urology Kansai Rosai Hospital  Amagasaki\u2010shi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaku","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Department of Urology Kansai Rosai Hospital  Amagasaki\u2010shi Japan"},{"name":"Department of Urology Hakuhokai Central Hospital  Amagasaki\u2010shi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0805-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-020-0897-9"},{"key":"e_1_2_11_4_1","first-page":"97\u20109","article-title":"Two cases of nonbacterial cystitis associated with nivolumab, the anti\u2010programmed\u2010death\u2010receptor\u20101 inhibitor","volume":"17","author":"Shimatani K","year":"2018","journal-title":"Urol. Case Rep."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13691-017-0298-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/iju5.12211"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S321965"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.6385"}],"container-title":["IJU Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iju5.12532","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T18:22:29Z","timestamp":1692642149000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iju5.12532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,24]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/iju5.12532"],"URL":"https:\/\/doi.org\/10.1002\/iju5.12532","archive":["Portico"],"relation":{},"ISSN":["2577-171X","2577-171X"],"issn-type":[{"value":"2577-171X","type":"print"},{"value":"2577-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,24]]},"assertion":[{"value":"2022-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}