{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:15:07Z","timestamp":1747149307561,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T00:00:00Z","timestamp":1666396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The main causes of secondary male infertility are varicocele and aging. It is rarely caused by adult\u2010onset hypopituitarism. The onset of hypopituitarism is often due to brain tumors, trauma, surgery, or congenital disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 29\u2010year\u2010old man was admitted to the hospital with complaints of decreased libido and semen volume, which lasted for 4\u00a0months. He had no abnormalities in adolescence and has a 2\u2010year\u2010old child. Blood tests showed low luteinizing hormone and follicle\u2010stimulating hormone, and semen tests showed azoospermia. Magnetic resonance imaging T1\u2010weighted images showed swelling and enhancement effect of the pituitary gland, and lymphocytic hypophysitis was suspected. After an Insulin\u2010thyroid\u2010stimulating hormone releasing hormone\u2010luteinizing hormone\u2010releasing hormone test, a decrease in luteinizing hormone\/follicle\u2010stimulating hormone secretion was considered. We diagnosed hypogonadotropic hypogonadism due to lymphocytic hypophysitis. Currently, the patient is being treated with a hormone replacement therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We experienced a case of hypogonadotropic hypogonadism due to lymphocytic hypophysitis discovered by secondary infertility.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12548","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T08:45:37Z","timestamp":1666428337000},"page":"51-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of hypogonadtropic hypogonadism due to hypophysitis discovered by secondary male infertility"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6058-9916","authenticated-orcid":false,"given":"Masatoshi","family":"Konishi","sequence":"first","affiliation":[{"name":"Department of Urology Osaka General Medical Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Maegawa","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka General Medical Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Tani","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka General Medical Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihisa","family":"Asakura","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka General Medical Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka General Medical Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Kakuta","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka General Medical Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Tsutahara","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka General Medical Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Komori","sequence":"additional","affiliation":[{"name":"Komori Clinic  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Takao","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka General Medical Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,22]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"184","article-title":"Secondary infertility and the aging male, overview","volume":"67","author":"Atif K","year":"2014","journal-title":"J. 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