{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:15:10Z","timestamp":1747149310815,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Immune checkpoint inhibitors such as programmed cell death\/\u2212ligand 1 inhibitor and cytotoxic T\u2010lymphocyte\u2010associated antigen\u20104 inhibitors have been widely used for various advanced malignancies. The mechanism of action for these inhibitors is the improvement of antitumor immunity via T\u2010cell modulation. On the contrary, immune\u2010related adverse events such as autoimmune colitis might arise in association with T\u2010cell activation. Upper gastrointestinal adverse events related to pembrolizumab have rarely been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 72\u2010year\u2010old man underwent laparoscopic radical cystectomy for muscle\u2010invasive bladder cancer (pT2N0M0). Multiple lymph node metastases appeared in the paraaortic region. First\u2010line chemotherapy comprising gemcitabine and carboplatin failed to stop disease progression. After the administration of pembrolizumab as second\u2010line treatment, the patient showed symptomatic gastroesophageal reflux disease. Esophagogastroduodenoscopic biopsy of the gastric body showed severe lymphoplasmacytic and neutrophilic infiltration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We present acute gastritis related to pembrolizumab. Early eradication therapy may be able to control immune checkpoint inhibitor\u2010related gastritis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12568","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T23:49:51Z","timestamp":1671580191000},"page":"128-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A case of acute lymphocytic gastritis related to treatment with pembrolizumab for metastatic urothelial carcinoma"],"prefix":"10.1002","volume":"6","author":[{"given":"Yousuke","family":"Fukiishi","sequence":"first","affiliation":[{"name":"Department of Urology National Hospital Organization Kochi National Hospital  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9079-0995","authenticated-orcid":false,"given":"Hideo","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi Medical School  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Kurano","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi Medical School  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Shugimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi Medical School  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi Medical School  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7338-8059","authenticated-orcid":false,"given":"Takashi","family":"Karasima","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi Medical School  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi Medical School  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.02.003"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx286"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503093"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2019-0700-OA"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1839-4303"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13118"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.636"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491862"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.9.5306"}],"container-title":["IJU Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12568","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iju5.12568","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T02:04:00Z","timestamp":1692324240000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iju5.12568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/iju5.12568"],"URL":"https:\/\/doi.org\/10.1002\/iju5.12568","archive":["Portico"],"relation":{},"ISSN":["2577-171X","2577-171X"],"issn-type":[{"type":"print","value":"2577-171X"},{"type":"electronic","value":"2577-171X"}],"subject":[],"published":{"date-parts":[[2022,12,20]]},"assertion":[{"value":"2022-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}