{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:15:10Z","timestamp":1747149310969,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Intravesical Bacillus Calmette\u2010Guerin administration is the standard therapy for high\u2010risk nonmuscle invasive bladder cancer and is usually well tolerated. However, some patients experience severe, potentially fatal, complications including interstitial pneumonitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 72\u2010year\u2010old female with scleroderma was diagnosed with bladder carcinoma in\u00a0situ. She developed severe interstitial pneumonitis with the first administration of intravesical Bacillus Calmette\u2010Guerin after the cessation of immunosuppressive agents. Six days after the first administration, she experienced dyspnea at rest, and computed tomography revealed scattered frosted shadows in the upper lung. The following day, she required intubation. We suspected drug\u2010induced interstitial pneumonia and started steroid pulse therapy for 3\u2009days, resulting in a complete response. No exacerbation of scleroderma symptoms or recurrence of cancer was observed 9\u2009months after Bacillus Calmette\u2010Guerin therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For patients receiving intravesical Bacillus Calmette\u2010Guerin therapy, close observation of the respiratory condition is necessary for early therapeutic intervention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12569","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T01:13:25Z","timestamp":1674609205000},"page":"133-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Drug\u2010induced interstitial pneumonia after intravesical Bacillus Calmette\u2010Guerin administration for bladder cancer with scleroderma"],"prefix":"10.1002","volume":"6","author":[{"given":"Fumie","family":"Yoshioka","sequence":"first","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8681-1407","authenticated-orcid":false,"given":"Taigo","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihito","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology Osaka University Graduate School of Medicine  Osaka Japan"},{"name":"Department of Thermo\u2010Therapeutics for Vascular Dysfunction Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Osaka 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