{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:03:54Z","timestamp":1784952234310,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Renal cell carcinoma with <jats:italic>TFEB<\/jats:italic> amplification is rare and reportedly aggressive. We herein report a case of renal cell carcinoma with <jats:italic>TFEB<\/jats:italic> translocation and amplification in which long\u2010term control was achieved by multimodal therapy including a vascular endothelial growth factor \u2010receptor inhibitor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 70\u2010year\u2010old man was referred to our institution for the treatment of renal cell carcinoma with multinodal metastases. Open nephrectomy and lymph node dissection were performed. Immunohistochemistry for transcription factor EB was positive, and fluorescent in\u00a0situ hybridization revealed <jats:italic>TFEB<\/jats:italic> rearrangement and amplification. The diagnosis was <jats:italic>TFEB<\/jats:italic>\u2010translocated and \u2010amplified renal cell carcinoma. <jats:italic>VEGFA<\/jats:italic> amplification was also demonstrated by fluorescent in\u00a0situ hybridization. The residual and recurrent tumors were treated and controlled for 52\u00a0months by vascular endothelial growth factor\u2010receptor target therapy, radiation therapy, and additional surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A good long\u2010term response to anti\u2010vascular endothelial growth factor drug therapy may be due to <jats:italic>VEGFA<\/jats:italic> amplification and subsequent vascular endothelial growth factor overexpression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12575","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T06:45:53Z","timestamp":1677739553000},"page":"161-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp><i>TFEB<\/i><\/scp>\u2010translocated and \u2010amplified renal cell carcinoma with <scp><i>VEGFA<\/i><\/scp> co\u2010amplification: A case of long\u2010term control by multimodal therapy including a vascular endothelial growth factor\u2010receptor inhibitor"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5118-4071","authenticated-orcid":false,"given":"Hajime","family":"Takamori","sequence":"first","affiliation":[{"name":"Department of Urology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko Miyagi","family":"Maeshima","sequence":"additional","affiliation":[{"name":"Department of Diagnositic Pathology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuma","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Baba","sequence":"additional","affiliation":[{"name":"International Research Center for Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eijiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Urology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Urology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.06.016"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000720"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11081110"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147649"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2015.02.003"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-00713-6"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505917"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0196-RA"},{"key":"e_1_2_13_10_1","first-page":"311","article-title":"A review of neoplasms with MITF\/MiT family translocations","volume":"37","author":"Wei S","year":"2022","journal-title":"Histol. Histopathol."},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0128-1"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14683"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.24"}],"container-title":["IJU Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12575","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iju5.12575","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T14:11:02Z","timestamp":1692713462000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iju5.12575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/iju5.12575"],"URL":"https:\/\/doi.org\/10.1002\/iju5.12575","archive":["Portico"],"relation":{},"ISSN":["2577-171X","2577-171X"],"issn-type":[{"value":"2577-171X","type":"print"},{"value":"2577-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"2022-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}