{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:28:04Z","timestamp":1789669684041,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The bladder exstrophy\u2010epispadias complex is a rare congenital disease. Urothelial carcinomas rarely occur in patients with this disease, and there have been few reports on its treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We report the case of a 44\u2010year\u2010old man with a hemorrhage from the external urethral meatus. He was diagnosed with bladder exstrophy\u2010epispadias complex and underwent urinary diversion with substitution cystoplasty and Mitrofanoff appendicovesicostomy. Because computed tomography and magnetic resonance imaging suggested invasive bladder carcinoma in the defunctionalized bladder, we performed a cystectomy. The patient was diagnosed with urothelial carcinoma with glandular differentiation. One month after the surgery, nivolumab adjuvant chemotherapy was administered. The patient showed no signs of recurrence or metastasis after the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first case of adjuvant nivolumab therapy for urothelial carcinoma with the bladder exstrophy\u2010epispadias complex.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12675","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T05:46:15Z","timestamp":1702100775000},"page":"101-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Urothelial carcinoma occurring in a defunctionalized bladder after urinary diversion due to the bladder exstrophy\u2010epispadias complex"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4430-0277","authenticated-orcid":false,"given":"Toshiharu","family":"Morikawa","sequence":"first","affiliation":[{"name":"Department of Nephro\u2010Urology Graduate School of Medical 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