{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:12:53Z","timestamp":1747149173613,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>17\u03b1\u2010Hydroxylase deficiency is a very rare disease reported to be associated with a risk of gonadal malignancy. We herein report a rare case of seminoma in a 46, XY patient with 17\u03b1\u2010hydroxylase deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 52\u2010year\u2010old woman presented with a 9\u2010cm pelvic tumor. At age 14, she had been identified as having the XY karyotype and 17\u03b1\u2010hydroxylase deficiency. However, she was not informed and did not consult the urology department. Laparoscopic gonadectomy was performed at the latest consultation, and seminoma was diagnosed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the third reported case of testicular tumor and the first of germ cell tumor in a 46, XY patient with 17\u03b1\u2010hydroxylase deficiency. Given the rarity and the risk of gonadal malignancy associated with 17\u03b1\u2010hydroxylase deficiency, the involvement of multidisciplinary specialists and prophylactic gonadectomy is considered crucial in its management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12737","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T05:24:33Z","timestamp":1716269073000},"page":"329-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seminoma in a 46, XY patient with 17\u03b1\u2010hydroxylase deficiency"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8925-5412","authenticated-orcid":false,"given":"Ken","family":"Maekawa","sequence":"first","affiliation":[{"name":"Department of Urology Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousuke","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koken","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaki","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Mitsumori","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(09)60342-9"},{"key":"e_1_2_13_3_1","first-page":"559","article-title":"Surgical therapy of 17\u03b1\u2010hydroxylase deficiency in 30 patients","volume":"38","author":"Jiang JF","year":"2016","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1116509"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2653"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.0032"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2010.08.018"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(08)70021-5"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.3839"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060521993965"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvac011"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-12-1-91"},{"key":"e_1_2_13_13_1","first-page":"527","article-title":"The undescended testis: diagnosis, treatment and long\u2010term consequences","volume":"106","author":"Mathers MJ","year":"2009","journal-title":"Dtsch. 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Int."}],"container-title":["IJU Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T01:48:32Z","timestamp":1720057712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iju5.12737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,20]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/iju5.12737"],"URL":"https:\/\/doi.org\/10.1002\/iju5.12737","archive":["Portico"],"relation":{},"ISSN":["2577-171X","2577-171X"],"issn-type":[{"type":"print","value":"2577-171X"},{"type":"electronic","value":"2577-171X"}],"subject":[],"published":{"date-parts":[[2024,5,20]]},"assertion":[{"value":"2024-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}