{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T07:03:14Z","timestamp":1757574194280,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T00:00:00Z","timestamp":1717891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Neurofibromatosis type 1 is a hereditary condition often associated with pheochromocytomas but rarely with malignant pheochromocytomas. Neurofibromatosis type 1 is often associated with bone lesions, which complicates the distinction between malignant and benign tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 46\u2010year\u2010old man with a medical history of neurofibromatosis type 1 presented with right abdominal pain. Computed tomography revealed a right adrenal tumor, and metaiodobenzylguanidine scintigraphy showed accumulation in the right adrenal gland and thoracic vertebrae. He was diagnosed with pheochromocytoma, and a right adrenalectomy was performed. After surgery, a bone biopsy was conducted on the spinal lesion, confirming metastasis of pheochromocytoma, prompting irradiation. After that, lung and liver metastases emerged, and chemotherapy with cyclophosphamide, vincristine, and dacarbazine was initiated; however, the disease progressed, and he died 11\u2009months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report a case of malignant pheochromocytoma associated with neurofibromatosis type 1 in which bone metastasis was difficult to diagnose.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12751","type":"journal-article","created":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T23:39:40Z","timestamp":1717976380000},"page":"336-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of malignant pheochromocytoma with neurofibromatosis type 1 having difficulty in differentiating spinal tumor"],"prefix":"10.1002","volume":"7","author":[{"given":"Kohei","family":"Segawa","sequence":"first","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1271-3521","authenticated-orcid":false,"given":"Yoshiyuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8681-1407","authenticated-orcid":false,"given":"Taigo","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Kakuta","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9369-4264","authenticated-orcid":false,"given":"Atsunari","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1336-4316","authenticated-orcid":false,"given":"Shinichiro","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Nonomura","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.4"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.26.11.704"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68171-2"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0709"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24063"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00992"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2022.10.100"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050814"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200205000-00002"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-13-0494"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2014.0109"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.1.71"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-21-0455"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.5.FOCUS15183"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860515)57:10<2006::AID-CNCR2820571022>3.0.CO;2-6"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.6297"},{"key":"e_1_2_12_18_1","first-page":"843","article-title":"Usefulness of 123I\u2010metaiodobenzylguanidine (MIBG) scintiscan in the diagnosis of juxta\u2010adrenal schwannoma","volume":"81","author":"Tommaselli AP","year":"1996","journal-title":"J. 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