{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:18:31Z","timestamp":1771917511672,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Primary squamous cell carcinoma of the prostate is rare, and genetic profiling of this disease has not been established yet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We present a case of primary squamous cell carcinoma in a patient with testicular dysgenesis syndrome. The patient was diagnosed with prostate squamous cell carcinoma following intractable dysuria, and his serum prostate\u2010specific antigen level was low. The patient had multiple lymph node and lung metastases, which led to administration of platinum\u2010based chemotherapy. Additionally, targeted next\u2010generation genome sequencing was performed to detect CDK12 mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early imaging studies should be considered, even if the patient's prostate\u2010specific antigen level is low when dysuria persists despite medical treatment. To the best of our knowledge, this is the first reported case of primary squamous cell carcinoma with a CDK12 mutation in a patient with TDS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12824","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T01:51:01Z","timestamp":1735869061000},"page":"125-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A case of testicular dysgenesis syndrome with squamous cell carcinoma of the prostate harboring a CDK12 mutation"],"prefix":"10.1002","volume":"8","author":[{"given":"Yasuaki","family":"Murata","sequence":"first","affiliation":[{"name":"Department of Urology Keio University School of Medicine  Shinjuku\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4371-4594","authenticated-orcid":false,"given":"Takeo","family":"Kosaka","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine  Shinjuku\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Genomics Unit, Keio Cancer Center Keio University School of Medicine  Shinjuku\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuto","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine  Shinjuku\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Pathology Keio University School of Medicine  Shinjuku\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yota","family":"Yasumizu","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine  Shinjuku\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9222-0999","authenticated-orcid":false,"given":"Kazuhiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine  Shinjuku\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nishihara","sequence":"additional","affiliation":[{"name":"Genomics Unit, Keio Cancer Center Keio University School of Medicine  Shinjuku\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mototsugu","family":"Oya","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine  Shinjuku\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)57013-5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/iju5.12466"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03545.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.5.972"},{"key":"e_1_2_12_6_1","first-page":"129","article-title":"Primary squamous cell carcinoma of the prostate: a case report","volume":"110","author":"Fukui K","year":"2019","journal-title":"Nihon Hinyokika Gakkai Zasshi"},{"key":"e_1_2_12_7_1","first-page":"77","article-title":"Primary squamous cell carcinoma of the prostate: a case report","volume":"39","author":"Kuwahara M","year":"1993","journal-title":"Hinyokika Kiyo"},{"key":"e_1_2_12_8_1","first-page":"39","article-title":"Primary squamous cell carcinoma of the prostate: a case report","volume":"53","author":"Inaba M","year":"2007","journal-title":"Hinyokika Kiyo"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000056618"},{"key":"e_1_2_12_10_1","first-page":"32","article-title":"Castration\u2010resistant prostate cancer patient presenting with whole genome doubling with CDK\u201012 mutation","volume":"15","author":"Baba Y","year":"2022","journal-title":"BMC Med. 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