{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:37:08Z","timestamp":1741754228995,"version":"3.38.0"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Muscle invasive bladder cancer during pregnancy is scarcely reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 41\u2010year\u2010old ex\u2010smoker Asian female, managed with clean intermittent catheterization for 3\u2009years due to neurogenic bladder caused by spinal cord disease, presented with gross hematuria at 10\u2009weeks of gestation. The patient was diagnosed with muscle invasive bladder cancer, cT3aN0M0. Maternal treatment was prioritized and gemcitabine plus cisplatin as neoadjuvant chemotherapy was started at 17\u2009weeks of gestation. Cesarean section was performed at 32\u2009weeks of gestation, followed by robot\u2010assisted radical cystectomy 3\u2009weeks later. Histopathological examination revealed urothelial carcinoma, G3, ypT3b. Postoperative adjuvant nivolumab followed by enfortumab vedotin was not successful and the patient died 8\u2009months after robot\u2010assisted radical cystectomy. Unfortunately, the premature infant with congenital heart disease died of necrotizing enterocolitis at 1\u2010month\u2010old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Gemcitabine plus cisplatin chemotherapy in the patient with muscle invasive bladder cancer during pregnancy was safe but ultimately resulted in unfavorable outcomes in this case.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12827","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T11:40:02Z","timestamp":1738064402000},"page":"138-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Muscle invasive bladder cancer treated with gemcitabine plus cisplatin as neoadjuvant chemotherapy during the second trimester of pregnancy"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2458-5686","authenticated-orcid":false,"given":"Takeshi","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Nephro\u2010Urologic Surgery and Andrology Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikadai","family":"Ryota","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010Urologic Surgery and Andrology Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinobu","family":"Ishiyama","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010Urologic Surgery and Andrology Mie University Graduate School of Medicine  Tsu Mie Japan"},{"name":"Department of Urology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Takakura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mie University School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momoko","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010Urologic Surgery and Andrology Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Owa","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010Urologic Surgery and Andrology Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taketomo","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010Urologic Surgery and Andrology Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Higashi","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010Urologic Surgery and Andrology Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouhei","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010Urologic Surgery and Andrology Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010Urologic Surgery and Andrology Mie University Graduate School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-024-02575-3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2020.08.084"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2020-001776"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01466-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-23-1234"},{"key":"e_1_2_11_7_1","first-page":"24","article-title":"A case of muscle invasive bladder cancer treated with systemic chemotherapy during pregnancy","volume":"1","author":"Stephen R","year":"2012","journal-title":"J. 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