{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:24:06Z","timestamp":1787869446800,"version":"build-2784847793"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Combination therapy comprising immune checkpoint inhibitors and molecular targeted therapies can be effective for metastatic non\u2010clear cell renal cell carcinoma. We describe a patient with metastatic papillary renal cell carcinoma that was completely pathologically resectable after combination treatment comprising lenvatinib and pembrolizumab and robot\u2010assisted radical nephrectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 35\u2010year\u2010old man was referred to our department for examination of a renal tumor that was diagnosed as left renal cell carcinoma with lymph node metastasis (cT3aN1M0). Because metastasis affected the renal artery, combination therapy comprising lenvatinib and pembrolizumab was initiated. After 6\u2009months of treatment, the patient underwent robot\u2010assisted radical nephrectomy. The pathological results indicated papillary renal cell carcinoma with no viable cells in the lymph nodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combination therapy comprising lenvatinib and pembrolizumab for unresectable papillary renal cell carcinoma may effectively allow radical resection and deferred cytoreductive nephrectomy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12830","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:38:27Z","timestamp":1738197507000},"page":"150-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of papillary renal cell carcinoma with para\u2010aortic lymph node metastasis that was completely resectable after treatment with combination therapy comprising lenvatinib and pembrolizumab and robot\u2010assisted radical nephrectomy"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4694-7388","authenticated-orcid":false,"given":"Takayuki","family":"Hosoi","sequence":"first","affiliation":[{"name":"Urology Takeda General Hospital  Aiduwakamatu Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Urology Ohta Nishinouchi Hospital  Koriyama Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7168-4315","authenticated-orcid":false,"given":"Akari","family":"Hiraguri","sequence":"additional","affiliation":[{"name":"Urology Takeda General Hospital  Aiduwakamatu Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3327-0782","authenticated-orcid":false,"given":"Yusuke","family":"Kirihana","sequence":"additional","affiliation":[{"name":"Urology Takeda General Hospital  Aiduwakamatu Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Koguchi","sequence":"additional","affiliation":[{"name":"Urology Takeda General Hospital  Aiduwakamatu Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Urology Aizu Clinic  Aiduwakamatu Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiharu","family":"Irisawa","sequence":"additional","affiliation":[{"name":"Urology Irisawa Clinic  Aiduwakamatu Fukushima 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