{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T04:25:32Z","timestamp":1751430332507,"version":"3.41.0"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K16788"],"award-info":[{"award-number":["22K16788"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Interstitial cystitis with Hunner lesion (IC\/HL) is an enigmatic, chronic inflammatory disease of the urinary bladder. Few documented cases have reported the IC\/HL involving the upper urinary tract.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 51\u2010year\u2010old Japanese woman with IC\/HL developed bilateral ureteral stenosis and associated hydronephrosis, resulting in increased serum creatinine concentrations. Cystography showed no evidence of bilateral vesicoureteral reflux or bladder deformity. Ureteroscopy showed severe ureteral stenosis due to mucosal hyperplasia at the mid\/upper levels of both ureters, leading to the insertion of bilateral ureteral stents. Histological examination of the ureteral lesions showed similar chronic inflammatory changes to the bladder lesions, which were compatible with IC\/HL. Bilateral ureteral stenosis persisted after a two\u2010year corticosteroid treatment (prednisolone, 7.5\u2009mg\/day), while IC\/HL symptoms have disappeared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IC\/HL could involve the upper ureters, and thus regular follow\u2010up imaging of upper urinary tracts in patients with IC\/HL is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.70010","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T05:45:43Z","timestamp":1745991943000},"page":"310-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Interstitial Cystitis With Hunner Lesions Involving Bilateral Ureters"],"prefix":"10.1002","volume":"8","author":[{"given":"Satoki","family":"Otsuka","sequence":"first","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1439-5640","authenticated-orcid":false,"given":"Yoshiyuki","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Urology Shinshu University School of Medicine  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daichi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Pathology, Graduate School of Medical Sciences Kanazawa University  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Niimi","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Kamei","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Tokyo  Tokyo 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Interstitial Cystitis Medicine Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9841-0857","authenticated-orcid":false,"given":"Haruki","family":"Kume","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Tokyo  Tokyo 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