{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:32Z","timestamp":1786977872038,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Immune checkpoint inhibitors (ICIs) are useful in the treatment of metastatic renal cell carcinoma. ICIs have been associated with a variety of immune\u2010related adverse events (irAEs), one of which is a sarcoid\u2010like reaction (SLR). SLR is often difficult to distinguish from cancer progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>The patient is a 71\u2010year\u2010old woman. She underwent laparoscopic nephrectomy after 4 courses of ipilimumab + nivolumab therapy for clear cell renal cell carcinoma with femoral bone metastasis. In the pathological examination, in addition to tumor\u2010infiltrating lymphocytes, numerous non\u2010caseating epithelioid cell granulomas were found in the tumor. The occurrence of non\u2010caseating epithelioid cell granuloma in a patient who did not meet the diagnostic criteria for systemic sarcoidosis was considered SLR due to ICI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We report the first case of a patient who underwent surgery for metastatic renal cell carcinoma after treatment with ICI and who was pathologically diagnosed with SLR in the kidney.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70027","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T02:44:46Z","timestamp":1744685086000},"page":"285-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sarcoid\u2010Like Reaction (\n                    <scp>SLR<\/scp>\n                    ) Associated With Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma"],"prefix":"10.1002","volume":"8","author":[{"given":"Kanta","family":"Fukushima","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Medical University Hachioji Medical Center  Tokyo Japan"},{"name":"Department of Urology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sota","family":"Mizukoshi","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical University Hachioji Medical Center  Tokyo Japan"},{"name":"Department of Urology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Ino","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical University Hachioji Medical Center  Tokyo Japan"},{"name":"Department of Urology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical University Hachioji Medical Center  Tokyo Japan"},{"name":"Department of Urology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumika","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Tokyo Medical University Hachioji Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Okimura","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Tokyo Medical University Hachioji Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munehide","family":"Nakatsugawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Tokyo Medical University Hachioji Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical University Hachioji Medical Center  Tokyo Japan"},{"name":"Department of Urology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"44","volume-title":"Acute and Chronic Inflammation in Robbins and Cotran Pathologic Basis of Disease","author":"Kumar V.","year":"2010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071714"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.02.017"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.05.032"},{"key":"e_1_2_9_6_1","first-page":"1185","article-title":"Radiographic Profiling of Immune\u2010Related Adverse Events in Advanced Melanoma Patients Treated With Ipilimumab. 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H.","year":"2015","journal-title":"Immunologic Research"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.04.031"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.02.024"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01440"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.6385"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.10.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-017-0300-z"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.051"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2019.100847"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00107912"}],"container-title":["IJU Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.70027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T19:43:25Z","timestamp":1746560605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iju5.70027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,14]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/iju5.70027"],"URL":"https:\/\/doi.org\/10.1002\/iju5.70027","archive":["Portico"],"relation":{},"ISSN":["2577-171X","2577-171X"],"issn-type":[{"value":"2577-171X","type":"print"},{"value":"2577-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,14]]},"assertion":[{"value":"2025-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}