{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T04:25:32Z","timestamp":1751430332563,"version":"3.41.0"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Congenital lipoid adrenal hyperplasia (CLAH) is a type of congenital adrenal hyperplasia characterized by reduced steroid production. Patients with this endocrine disorder as well as chromosome 46,XY have testes and female external genitalia. Because these individuals are usually raised as female, the testes are removed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 22\u2010day\u2010old female infant with fever and poor feeding was diagnosed with hypoadrenocorticism. Chromosome test results identified a 46,XY karyotype. Therefore, CLAH was diagnosed. At 1\u2009year and 6\u2009months of age, the patient underwent laparoscopic gonadectomy. Pathological testing of the testes revealed fat deposits in Leydig cells and decreased germ cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CLAH with chromosome 46,XY may be complicated by spermatogenesis deficiency.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.70048","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T04:40:07Z","timestamp":1748407207000},"page":"386-389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histopathological Features of the Testes of a Patient With Congenital Lipoid Adrenal Hyperplasia"],"prefix":"10.1002","volume":"8","author":[{"given":"Takuya","family":"Sakata","sequence":"first","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9624-2009","authenticated-orcid":false,"given":"Kentaro","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1327-6631","authenticated-orcid":false,"given":"Hidenori","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology Nagoya City University Graduate School of Medical Sciences  Nagoya 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