{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:47:11Z","timestamp":1787507231869,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T00:00:00Z","timestamp":1753574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Leydig cell tumors (LCTs), constituting 1%\u20133% of testicular tumors, are mostly benign, but malignant cases present treatment challenges. We report a malignant LCT case with a notable response to mitotane.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 43\u2010year\u2010old male presented with a right testicular induration and was diagnosed with a Leydig cell tumor following orchiectomy. BEP chemotherapy was initiated for the liver metastases, but after four cycles, new lymph node and bone lesions appeared. Mitotane was started, which markedly reduced liver and nodal metastases. However, due to fatigue, anorexia, and nipple discomfort, mitotane was discontinued. The disease progressed, and the patient died 4\u2009years post\u2010diagnosis and 14\u2009months after starting mitotane.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mitotane shows promise in treating malignant LCTs, but careful management of adverse effects is necessary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70078","type":"journal-article","created":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T22:34:06Z","timestamp":1753655646000},"page":"498-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mitotane Treatment for Malignant Leydig Cell Tumor: A Case Report"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4080-9904","authenticated-orcid":false,"given":"Daiki","family":"Katsura","sequence":"first","affiliation":[{"name":"Department of Urology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mototsugu","family":"Muramaki","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Amagasaki General Medical Center  Amagasak Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9811-0604","authenticated-orcid":false,"given":"Takashi","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Amagasaki General Medical Center  Amagasak Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Amagasaki General Medical Center  Amagasak Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Yutaka","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Amagasaki General Medical Center  Amagasak Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Amagasaki General Medical Center  Amagasak Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Amagasaki General Medical Center  Amagasak Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Amagasaki General Medical Center  Amagasak 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