{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T02:44:33Z","timestamp":1762137873603,"version":"build-2065373602"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We present a case of carcinoma in\u00a0situ (CIS) of the bilateral upper urinary tract (UUT) in which long\u2010term complete remission was achieved through retrograde perfusion of Bacillus Calmette\u2013Gu\u00e9rin (BCG) via open\u2010ended ureteral catheters following the failure of endoluminal therapy using double\u2010J stents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 52\u2010year\u2010old male patient was diagnosed with CIS of the bilateral UUT and bladder. Intravesical BCG instillation using double\u2010J stents failed to eradicate persistently positive catheter urine cytology from the bilateral UUT. Since the patient strongly desired kidney\u2010sparing treatment, retrograde BCG perfusion via open\u2010ended ureteral catheter was performed. This treatment resulted in durable complete remission lasting 3\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Retrograde BCG treatment via double\u2010J stent may result in suboptimal efficacy due to limited drug exposure to the UUT urothelium. In cases in which kidney\u2010sparing treatment is required, retrograde BCG perfusion via open\u2010ended ureteral catheters may be considered a viable therapeutic option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70092","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T10:40:34Z","timestamp":1758105634000},"page":"575-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Complete Remission of Bilateral Upper Tract Carcinoma In\u00a0Situ Following Retrograde Bacillus Calmette\u2013Gu\u00e9rin (\n                    <scp>BCG<\/scp>\n                    ) Instillation via Open\u2010Ended Ureteral Catheters After Failure Using Double\u2010J Stents"],"prefix":"10.1002","volume":"8","author":[{"given":"Nanaka","family":"Katsurayama","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Adachi Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihide","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Adachi Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Adachi Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Adachi Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Adachi Medical Center  Tokyo Japan"},{"name":"Department of Urology Chiba\u2010Nishi General Hospital  Matsudo City Chiba Prefecture Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Adachi Medical Center  Tokyo Japan"},{"name":"Department of Urology Tokiwakai Jyoban Hospital  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Adachi Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Toki","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Adachi Medical Center  Tokyo 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