{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T02:44:35Z","timestamp":1762137875888,"version":"build-2065373602"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Large cell neuroendocrine carcinoma (LCNEC) of the bladder is rare and aggressive. Reports of metastasectomy for single distant metastases are even rarer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 49\u2010year\u2010old man was admitted to our hospital with gross hematuria. Cystoscopy, magnetic resonance imaging, and computed tomography revealed invasive bladder cancer without metastasis. He underwent transurethral resection of the bladder tumor, and histopathological examination confirmed LCNEC. The patient received neoadjuvant chemotherapy followed by partial cystectomy. Nineteen months postoperatively, a solitary metastasis was detected in the right axillary lymph node, and at 44\u2009months, another solitary metastasis appeared in the subcutaneous tissue outside the right scapula. Both metastases were surgically resected, and no additional treatment was administered. At the time of this writing, there had been no recurrence or metastasis for 42\u2009months following the second metastasectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Metastasectomy may be an effective treatment option for solitary metastasis of LCNEC of the bladder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70102","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:10:06Z","timestamp":1759363806000},"page":"612-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Large Cell Neuroendocrine Carcinoma of the Bladder With Long\u2010Term Control by Metastasectomy"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3434-3852","authenticated-orcid":false,"given":"Naoto","family":"Takaoka","sequence":"first","affiliation":[{"name":"Department of Urology Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Yamane","sequence":"additional","affiliation":[{"name":"Department of Urology Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuma","family":"Hiramatsu","sequence":"additional","affiliation":[{"name":"Department of Urology Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Tsuchihashi","sequence":"additional","affiliation":[{"name":"Department of Urology Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kawanishi","sequence":"additional","affiliation":[{"name":"Department of Urology Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Yamashiro","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomitaka","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Tenri Hospital  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Urology Tenri Hospital  Nara 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Cystectomy in a 76 Year Old Patient Suffering From Small Cell Carcinoma of the Urinary Bladder","volume":"66","author":"Starownik R.","year":"2013","journal-title":"Central European Journal of Urology"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1337997"}],"container-title":["IJU Case 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