{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:17:28Z","timestamp":1769537848419,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Metastatic papillary renal cell carcinoma (PRCC) is associated with a poor prognosis. Many patients with PRCC respond to first\u2010 and second\u2010line systemic chemotherapy treatments; however, few respond to late\u2010sequence treatment. We describe a case of a long\u2010term response to fourth\u2010line axitinib after the use of tyrosine kinase inhibitor therapy for metastatic papillary renal cell carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 37\u2010year\u2010old male presented with hematuria and left back pain. Following systemic examination, he was diagnosed with left renal cell carcinoma cT3aN0M1. He underwent left radical nephrectomy. The pathological diagnosis was PRCC type 2. After using sunitinib, cabozantinib, and nivolumab, axitinib was selected as fourth\u2010line systemic therapy, resulting in a reduction in multiple liver metastases and 15\u2009months of response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Late\u2010sequence treatment with axitinib following prior use of tyrosine kinase inhibitor therapy resulted in a long\u2010term response in a patient with metastatic papillary renal cell carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70115","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T14:24:12Z","timestamp":1763130252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of a Durable Partial Response to Late\u2010Line Axitinib Following Prior Use of Tyrosine Kinase Inhibitors in Metastatic Papillary Renal Cell Carcinoma"],"prefix":"10.1002","volume":"9","author":[{"given":"Naoto","family":"Hodotsuka","sequence":"first","affiliation":[{"name":"Department of Urology Nippon Medical School Chiba Hokusoh Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5732-5779","authenticated-orcid":false,"given":"Yasutomo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School Chiba Hokusoh Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Yamaki","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School Chiba Hokusoh Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School Chiba Hokusoh Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyota","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School Chiba Hokusoh Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuma","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School Chiba Hokusoh Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eigo","family":"Kuribayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School Chiba Hokusoh Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School Hospital  Tokyo 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