{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:30:04Z","timestamp":1769538604527,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We report a case in which combination therapy with enfortumab vedotin (EV) and pembrolizumab proved effective in treating non\u2010muscle\u2010invasive bladder cancer (NMIBC) accompanied by multiple bone metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 61\u2010year\u2010old man with NMIBC underwent eight transurethral resections of bladder tumor (TURBTs) at another hospital over 4\u2009years. During the eighth TURBT, carcinoma in\u00a0situ was detected, and the patient was treated with intravesical Bacillus Calmette\u2010Gu\u00e9rin (BCG) therapy. A computed tomography scan performed at our hospital 1.5\u2009years after BCG therapy revealed multiple osteosclerotic lesions. Cystoscopy and bladder magnetic resonance imaging revealed no obvious tumorous lesions. An incisional biopsy of the sternum confirmed the diagnosis of multiple bone metastases originating from NMIBC. The patient was started on combination therapy with EV and pembrolizumab. After 5\u2009months, bone scintigraphy revealed decreased accumulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combination therapy with EV and pembrolizumab was also effective in treating NMIBC with multiple bone metastases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70119","type":"journal-article","created":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T22:58:59Z","timestamp":1766703539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiple Bone Metastases From Non\u2010Muscle Invasive Bladder Cancer Responding to Combination Therapy With Enfortumab Vedotin and Pembrolizumab: A Case Report"],"prefix":"10.1002","volume":"9","author":[{"given":"Shin","family":"Kanemoto","sequence":"first","affiliation":[{"name":"Department of Urology Kochi Health Science Center  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-7666","authenticated-orcid":false,"given":"Shinkuro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi Medical School  Nankoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Hino","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi Health Science Center  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0926-1897","authenticated-orcid":false,"given":"Kazuma","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi Health Science Center  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mototsune","family":"Kakizaki","sequence":"additional","affiliation":[{"name":"Department of Pathology Kochi Health Science Center  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi Health Science Center  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Fukata","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi Medical School  Nankoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoji","family":"Arata","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi Health Science Center  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi Medical School  Nankoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi Health Science Center  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.07.062"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65157-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13509"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.031"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/iju5.12775"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2014.05.008"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-022-02664-5"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194007000-00016"},{"key":"e_1_2_11_10_1","unstructured":"\u201cNCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Bladder Cancer. Version 2 \u201d (2025) https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/bladder.pdf."},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312117"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14796694.2025.2482363"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000938"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-022-03328-1"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/PO-24-00470"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01983"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00147-9"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00178-5"}],"container-title":["IJU Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.70119","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iju5.70119","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.70119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T05:08:08Z","timestamp":1769490488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iju5.70119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,25]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/iju5.70119"],"URL":"https:\/\/doi.org\/10.1002\/iju5.70119","archive":["Portico"],"relation":{},"ISSN":["2577-171X","2577-171X"],"issn-type":[{"value":"2577-171X","type":"print"},{"value":"2577-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,25]]},"assertion":[{"value":"2025-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70119"}}