{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T18:17:27Z","timestamp":1769537847578,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Direct liver invasion by renal cell carcinoma (RCC) is rare and often precludes margin\u2010negative resection. Herein, we report a case where neoadjuvant treatment with avelumab plus axitinib downstaged the disease, enabling complete surgical resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 67\u2010year\u2010old woman presented with gross hematuria. Computed tomography revealed a 70\u2010mm right renal mass with direct liver invasion. Core biopsy confirmed clear\u2010cell RCC and clinical stage cT4N0M0. She received ten cycles of avelumab (10\u2009mg\/kg, biweekly) plus axitinib (10\u2009mg\/day), resulting in tumor shrinkage to 35\u2009mm. She underwent open radical nephrectomy with partial hepatectomy, achieving negative surgical margins. Histological examination revealed hepatic parenchymal invasion, with no viable tumor at the inked hepatic margin. Adjuvant therapy was not administered. The patient has remained disease\u2010free for 24\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In select cases of organ\u2010invasive non\u2010metastatic RCC, short\u2010term neoadjuvant therapy with avelumab plus axitinib may allow for complete resection and prolonged disease control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70124","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:18:48Z","timestamp":1767917928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neoadjuvant Avelumab Plus Axitinib Enabling Curative Resection of Renal Cell Carcinoma With Direct Liver Invasion: A Case Report"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7240-6113","authenticated-orcid":false,"given":"Fumihiro","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Urology Gifu Prefectural Tajimi Hospital  Tajimi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Gifu Prefectural Tajimi Hospital  Tajimi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaku","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Gifu Prefectural Tajimi Hospital  Tajimi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Kamijo","sequence":"additional","affiliation":[{"name":"Department of Urology Gifu Prefectural Tajimi Hospital  Tajimi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Urology Gifu Prefectural Tajimi Hospital  Tajimi 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Approaches to the Treatment of Advanced or Metastatic Renal Cell Carcinoma","volume":"40","author":"Tenold M.","year":"2020","journal-title":"American Society of Clinical Oncology Educational Book"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.10.010"}],"container-title":["IJU Case 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