{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T17:48:01Z","timestamp":1769536081400,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Acquired factor V (FV) deficiency is a rare bleeding disorder requiring careful management, especially in hemodialysis (HD) patients who regularly receive anticoagulants. We present a case of recurrent acquired FV deficiency in a dialysis patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 76\u2010year\u2010old man on HD with a history of acquired FV deficiency developed third\u2010degree burns and persistent bleeding. Lab tests confirmed the recurrence of the deficiency. Initial treatments with rituximab and cyclophosphamide were ineffective. When prednisolone was rechallenged, the activity of coagulation FV was rapidly improved, and coagulation function was confirmed to have returned to normal. HD was managed without anticoagulants during critical periods. No major bleeding events were observed during HD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case underscores the complexities of managing acquired FV deficiency in patients on HD. It highlights the importance of individualized anticoagulation strategies and close monitoring of coagulation profiles to prevent bleeding complications and ensure the safety of HD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70129","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T01:12:20Z","timestamp":1765761140000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Acquired Factor V Deficiency in a Hemodialysis Patient: A Case Report With Literature Review"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5257-6293","authenticated-orcid":false,"given":"Akihiko","family":"Sugino","sequence":"first","affiliation":[{"name":"Department of Urology Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8416-2394","authenticated-orcid":false,"given":"Yoshiyuki","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Department of Urology Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7142-8040","authenticated-orcid":false,"given":"Shugo","family":"Harashima","sequence":"additional","affiliation":[{"name":"Department of Urology Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8887-0489","authenticated-orcid":false,"given":"Yusaku","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Urology Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikiya","family":"Kajita","sequence":"additional","affiliation":[{"name":"Department of Hematology Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Gunma University Graduate School of Medicine  Maebashi Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Handa","sequence":"additional","affiliation":[{"name":"Department of Hematology Gunma University Graduate School of Medicine  Maebashi Gunma 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07708.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e3283424883"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1740149"},{"issue":"1","key":"e_1_2_9_5_1","article-title":"Development of Acquired Factor V Inhibitor After Surgical Procedure Without the Use of Fibrin Tissue Adhesives: A Case Report","volume":"13","author":"Hirata H.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.70003"},{"issue":"5","key":"e_1_2_9_7_1","first-page":"445","article-title":"Successful Management of Acquired Factor V Deficiency Developing Shortly After Induction of Hemodialysis","volume":"61","author":"Matsumoto A.","year":"2020","journal-title":"Rinsh\u014d 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