{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T01:55:03Z","timestamp":1774576503664,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Primary malignant neoplasms of the epididymis are rare. In this case report, we describe clear cell carcinoma associated with papillary cystadenoma of the epididymis (PCE).<\/jats:p>\n <\/jats:sec>\n \n Case Presentation<\/jats:title>\n A 77\u2010year\u2010old man presented with a painless, enlarged left scrotum. Magnetic resonance imaging (MRI) revealed two different abnormal signals in the left epididymis. A left high inguinal orchiectomy and histopathological examination revealed a benign component consistent with PCE and a malignant component showing solid growth with cell nuclear enlargement, atypical mitotic figures, and invasion into surrounding tissues. The final diagnosis was malignant transformation to clear cell carcinoma of PCE.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Although this epididymis tumor may follow an indolent course, the presence of areas with higher proliferative potential suggests surgical excision be recommended as definitive treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/iju5.70140","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:08:41Z","timestamp":1772986121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Clear Cell Carcinoma Associated With Papillary Cystadenoma Originating in the Epididymis"],"prefix":"10.1002","volume":"9","author":[{"given":"Hiroko","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences Nagoya Japan"},{"name":"Department of Urology Kainan Hospital Yatomi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7638-6048","authenticated-orcid":false,"given":"Taku","family":"Naiki","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuzi","family":"Tsuyuki","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kainan Hospital Yatomi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Kito","sequence":"additional","affiliation":[{"name":"Department of Urology Kainan Hospital Yatomi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nozaki","sequence":"additional","affiliation":[{"name":"Department of Urology Kainan Hospital Yatomi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Urology Kainan Hospital Yatomi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Yasui","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,7]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"137","article-title":"A Case of Papillary Cystadenoma of Epididymis","volume":"35","author":"Miyake O.","year":"1989","journal-title":"Hinyokika Kiyo"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.55418\/9781933477220"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1993.tb01156.x"},{"key":"e_1_2_10_5_1","first-page":"321","article-title":"Clear Cell Papillary Cystadenocarcinoma of the Epididymis: A Case Report and Immunohistochemistry of Markers for Renal Cell Carcinoma","volume":"28","author":"Nozawa T.","year":"2013","journal-title":"Histology and Histopathology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195603\/04)9:2<403::AID-CNCR2820090226>3.0.CO;2-Q"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5858\/134.4.630"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37173-2"},{"key":"e_1_2_10_9_1","first-page":"139","article-title":"Papillary Cystadenocarcinoma of the Epididymis\u2010 Report of a Case","volume":"45","author":"Wang T. Y.","year":"1990","journal-title":"Zhonghua Yi Xue Za Zhi (Taipei)"},{"key":"e_1_2_10_10_1","article-title":"Epididymal Papillary Cystadenocarcinoma Metastasizing to the Testis in a Patient With Infertility Managed With Onco\u2010Micro TeSE","volume":"11","author":"Nisha P.","year":"2016","journal-title":"Journal of Surgical Case Reports"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.5980\/jpnjurol.107.193"}],"container-title":["IJU Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.70140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iju5.70140","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.70140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T01:21:43Z","timestamp":1774574503000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iju5.70140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/iju5.70140"],"URL":"https:\/\/doi.org\/10.1002\/iju5.70140","archive":["Portico"],"relation":{},"ISSN":["2577-171X","2577-171X"],"issn-type":[{"value":"2577-171X","type":"print"},{"value":"2577-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70140"}}