{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T04:04:25Z","timestamp":1779681865873,"version":"3.53.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Essential renal bleeding is rare and lacks standardized treatment; organ\u2010preserving options are critical in older patients with impaired renal function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A woman in her early 80s with atrial fibrillation treated with edoxaban, chronic heart failure, and advanced chronic kidney disease presented with gross hematuria and bladder tamponade. Bleeding was localized to the right renal pelvis and ureter, with no tumor, urolithiasis, vascular malformation, or glomerular disease; essential renal bleeding was diagnosed. Hematuria persisted despite edoxaban discontinuation, red blood cell and plasma transfusions, and carbazochrome sodium sulfonate administration. Isolated factor XIII activity was 22%. Intravenous plasma\u2010derived factor XIII concentrate achieved sustained hemostasis, renal function remained stable, and reduced\u2010dose edoxaban was safely resumed. Hematuria did not recur within 24\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this population, factor XIII deficiency may contribute to persistent unilateral hematuria despite normal conventional coagulation tests.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70182","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:48:14Z","timestamp":1777888094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Essential Renal Bleeding Presenting as Persistent Unilateral Hematuria Successfully Treated With Factor\n                    <scp>XIII<\/scp>\n                    Replacement Therapy: A Case Report"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4548-966X","authenticated-orcid":false,"given":"Moe","family":"Toyoshima","sequence":"first","affiliation":[{"name":"Department of Urology Iwate Medical University  Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-2831","authenticated-orcid":false,"given":"Shigekatsu","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Department of Urology Iwate Medical University  Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arisa","family":"Machida","sequence":"additional","affiliation":[{"name":"Department of Urology Iwate Medical University  Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kie","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Urology Iwate Medical University  Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Ikarashi","sequence":"additional","affiliation":[{"name":"Department of Urology Iwate Medical University  Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6089-7620","authenticated-orcid":false,"given":"Renpei","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Urology Iwate Medical University  Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsugu","family":"Kanehira","sequence":"additional","affiliation":[{"name":"Department of Urology Iwate Medical University  Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Sugimura","sequence":"additional","affiliation":[{"name":"Department of Urology Iwate Medical University  Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2720-9640","authenticated-orcid":false,"given":"Wataru","family":"Obara","sequence":"additional","affiliation":[{"name":"Department of Urology Iwate Medical University  Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1924.02660180008002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119693741.ch51"},{"key":"e_1_2_9_4_1","first-page":"14","article-title":"Hematuria of Renal Origin","volume":"8","author":"Hitt M. 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