{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T07:04:02Z","timestamp":1785135842609,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Malignant transformation of mixed epithelial and stromal tumors of the kidney (MESTK) is extremely rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 39\u2010year\u2010old man with gross hematuria was suspected to have renal cell carcinoma, measuring 13\u2009cm in diameter. No distant metastases were observed. The patient underwent laparoscopic left nephrectomy. Histopathological examination revealed malignant sarcomatous transformation of MESTK. Immunohistochemically, the tumor was positive for PAX8, CD10, and desmin, as well as for estrogen, progesterone, and androgen receptors. Comprehensive genomic profiling did not yield any treatment recommendations or relevant information. The patient will be closely monitored for any signs of recurrence or metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The associated prognosis for patients with nonmetastatic MESTKs exhibiting malignant transformation is unknown; however, strict follow\u2010up is recommended due to the histological grade of malignancy and local invasion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70194","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T06:57:21Z","timestamp":1779778641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Malignant\/Sarcomatous Transformation of Mixed Epithelial and Stromal Tumor of the Kidney: A Case Report"],"prefix":"10.1002","volume":"9","author":[{"given":"Kentaro","family":"Arinami","sequence":"first","affiliation":[{"name":"Department of Urology Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital  Minamiuonuma Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozue","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pathology Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital  Minamiuonuma Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital  Minamiuonuma Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurie","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital  Minamiuonuma Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital  Minamiuonuma Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Urology Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital  Minamiuonuma Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5684-8364","authenticated-orcid":false,"given":"Tsutomu","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Urology Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital  Minamiuonuma Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/133.9.1483"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000733"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2022.152088"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2022.03.011"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2024.102689"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.06.016"},{"issue":"5","key":"e_1_2_11_8_1","first-page":"2658","article-title":"Malignant Mixed Epithelial and Stromal Tumor of the Kidney: The Second Male Case and Review of Literature","volume":"7","author":"Zou L.","year":"2014","journal-title":"International Journal of Clinical and Experimental 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