{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T07:04:01Z","timestamp":1785135841793,"version":"3.55.0"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The combination of enzalutamide and radium\u2010223 has demonstrated clinical efficacy in metastatic castration\u2010resistant prostate cancer; however, real\u2010world evidence remains limited, particularly with PSA\u2013discordant progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 74\u2010year\u2010old man with high\u2010risk localized prostate cancer was treated with androgen deprivation therapy followed by definitive external beam radiotherapy. Eight months later, the disease progressed radiographically with extensive bone, nodal, and solitary liver metastases, while prostate\u2010specific antigen levels remained persistently low, consistent with prostate\u2010specific antigen\u2013discordant progression. Bone turnover markers and disease activity markers were markedly elevated. Combination therapy with enzalutamide and radium\u2010223 was initiated, and six cycles of radium\u2010223 were completed. Following treatment, skeletal disease activity and bone turnover markers improved markedly. Apart from grade 3 anemia requiring transfusion, no severe adverse events occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case suggests that enzalutamide combined with radium\u2010223 may provide clinical benefit in metastatic castration\u2010resistant prostate cancer with PSA\u2013discordant progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70224","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:56:08Z","timestamp":1783990568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Meaningful Radiographic and Metabolic Response to Enzalutamide Plus Radium\u2010223 Therapy in Metastatic Castration\u2010Resistant Prostate Cancer With\n                    <scp>PSA<\/scp>\n                    \u2010Discordant Progression: A Case Report"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8475-7812","authenticated-orcid":false,"given":"Yamato","family":"Numata","sequence":"first","affiliation":[{"name":"Department of Urology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-9324","authenticated-orcid":false,"given":"Go","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2671-7064","authenticated-orcid":false,"given":"Jun","family":"Akatsuka","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Mikami","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School  Tokyo 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