{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:07:16Z","timestamp":1790323636877,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Urethral metastasis of prostate cancer is exceptionally rare, particularly in castration\u2010resistant disease. Therapy\u2010induced neuroendocrine prostate cancer (t\u2010NEPC) is an aggressive variant with limited treatment options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 72\u2010year\u2010old man, 14\u2009years after diagnosis of prostate adenocarcinoma treated with androgen deprivation therapy, presented with hematuria and dysuria. Prostate\u2010specific antigen was 2.05\u2009ng\/mL and neuron\u2010specific enolase was 28.0\u2009ng\/mL. Urethroscopy revealed papillary tumors in the pendulous urethra. Histology showed high\u2010grade adenocarcinoma with a small cell carcinoma component, positive for synaptophysin and prostate\u2010specific antigen. Genomic profiling demonstrated PTEN loss, TP53 mutation, and androgen receptor amplification. Platinum\u2010based chemotherapy with external\u2010beam radiotherapy achieved durable urethral local control despite later distant progression; the patient survived 2\u2009years 10\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Platinum\u2010based chemoradiotherapy may provide durable local control of urethral metastasis from t\u2010NEPC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70234","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T07:20:36Z","timestamp":1786087236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Urethral Metastasis of Therapy\u2010Induced Neuroendocrine Prostate Cancer Successfully Managed With Chemoradiotherapy: A Case Report"],"prefix":"10.1002","volume":"9","author":[{"given":"Toshiaki","family":"Kayaba","sequence":"first","affiliation":[{"name":"Department of Urology Jichi Medical University Saitama Medical Center  Saitama Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9464-6424","authenticated-orcid":false,"given":"Satoshi","family":"Washino","sequence":"additional","affiliation":[{"name":"Department of Urology Jichi Medical University Saitama Medical Center  Saitama Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Hayase","sequence":"additional","affiliation":[{"name":"Department of Urology Jichi Medical University Saitama Medical Center  Saitama Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yazaki","sequence":"additional","affiliation":[{"name":"Department of Urology Jichi Medical University Saitama Medical Center  Saitama Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimitoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Urology Jichi Medical University Saitama Medical Center  Saitama Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9867-0229","authenticated-orcid":false,"given":"Tomoaki","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Urology Jichi Medical University Saitama Medical Center  Saitama Saitama 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