{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:07:18Z","timestamp":1790323638645,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Immediate postoperative intravesical chemotherapy following transurethral resection of bladder tumor (TURBT) is the standard procedure aimed at reducing recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>An 84\u2010year\u2010old man was diagnosed with an incidental 13\u2010mm intravesical tumor during screening for biochemical recurrence following radiation therapy for prostate cancer. Accordingly, he underwent TURBT, followed by immediate postoperative intravesical chemotherapy with epirubicin. On postoperative day 2, he developed abdominal pain. Computed tomography demonstrated bladder perforation accompanied by retroperitoneal free air. He was diagnosed with extraperitoneal bladder perforation and thus managed with urethral catheterization; however, conservative treatment failed. Consequently, surgical repair with debridement was performed. Pale whitish granulation tissue was observed within the perivesical fat, suggesting epirubicin extravasation. Subsequently, cystography performed 28\u2009days after bladder repair showed no contrast extravasation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Surgical treatment should be considered as a potential treatment option for patients with suspected chemotherapy extravasation in whom conservative management is unsuccessful.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70235","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:14:01Z","timestamp":1785284041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bladder Perforation Following Transurethral Resection of Bladder Tumor With Immediate Intravesical Instillation of Epirubicin"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7486-1831","authenticated-orcid":false,"given":"Junya","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Urology, Faculty of Medicine Miyazaki University Hospital  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4833-1709","authenticated-orcid":false,"given":"Atsuro","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Miyazaki University Hospital  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2847-9697","authenticated-orcid":false,"given":"Chie","family":"Onizuka","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Miyazaki University Hospital  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Akioka","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Miyazaki University Hospital  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Miyazaki University Hospital  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimpei","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Miyazaki University Hospital  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Miyazaki University Hospital  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Horinouchi","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Miyazaki University Hospital  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Kamoto","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Miyazaki University Hospital  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-013-1197-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.05.050"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.06.038"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2724-6051.21.04436-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341900"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(03)00151-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2004.05.003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000089179"},{"issue":"5","key":"e_1_2_8_10_1","first-page":"4269","article-title":"Vesicoenteric, Vesicovaginal, Vesicocutaneous Fistula \u2010An Unusual Complication With Intravesical Mitomycin","volume":"15","author":"Dangle P. 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