{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:06:58Z","timestamp":1790323618162,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Bone marrow carcinomatosis (BMC) is a rare manifestation of metastatic urothelial carcinoma (UC) that may mimic hematologic disease and cause severe cytopenia, diagnostic difficulty, and rapid clinical deterioration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 65\u2010year\u2010old man presented with back pain, thrombocytopenia, and leukoerythroblastosis. Bone marrow aspiration resulted in a dry tap, but biopsy revealed diffuse carcinoma\u2010cell infiltration consistent with UC, establishing BMC as the cause of marrow failure. Because of profound marrow dysfunction, reduced\u2010dose gemcitabine and cisplatin chemotherapy was initiated, leading to hematologic recovery and radiologic improvement. The patient subsequently received standard\u2010dose chemotherapy and avelumab maintenance and survived for 12.4\u2009months after diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Histologic confirmation is essential to distinguish UC\u2010related BMC from primary hematologic disease and may support individualized systemic treatment in carefully selected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70261","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:14:45Z","timestamp":1789949685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Definitive Histologic Diagnosis of Bone Marrow Carcinomatosis Followed by Dose\u2010Adjusted Chemotherapy in Metastatic Urothelial Carcinoma: A Case Report"],"prefix":"10.1002","volume":"9","author":[{"given":"Shohei","family":"Yamaki","sequence":"first","affiliation":[{"name":"Department of Urology Nippon Medical School Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0787-9321","authenticated-orcid":false,"given":"Yuki","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2671-7064","authenticated-orcid":false,"given":"Jun","family":"Akatsuka","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5555-5789","authenticated-orcid":false,"given":"Hikaru","family":"Mikami","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0570-8173","authenticated-orcid":false,"given":"Shunsuke","family":"Ikuma","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0427-0644","authenticated-orcid":false,"given":"Kotaro","family":"Obayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3092-1014","authenticated-orcid":false,"given":"Masato","family":"Yanagi","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School Hospital  Tokyo 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