{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:53:21Z","timestamp":1791183201953,"version":"4.1.0"},"reference-count":7,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We report a case of de novo prostatic adenosquamous carcinoma with a minute squamous component in the initial biopsy and early liver metastasis despite a marked prostate\u2010specific antigen response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 72\u2010year\u2010old man was diagnosed with locally advanced prostate cancer with nodal and multiple bone metastases. Prostate biopsy initially showed adenocarcinoma with a Gleason score of 4\u2009+\u20095. After leuprolide and abiraterone plus radiotherapy, prostate\u2010specific antigen decreased from 13.0 to 0.22\u2009ng\/mL; however, a liver metastasis developed. Re\u2010evaluation of the prostate biopsy revealed minute squamous differentiation, and liver biopsy showed metastatic squamous cell carcinoma. Immunohistochemistry showed retained MLH1 and PMS2 expression with loss of MSH2 and MSH6 in both specimens. Genomic profiling showed microsatellite instability\u2010high status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Repeat biopsy and molecular\u2010pathological reassessment may be important when radiographic progression is discordant with prostate\u2010specific antigen kinetics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70262","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:45:17Z","timestamp":1791182717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prostatic Adenosquamous Carcinoma With a Minute Squamous Component in the Initial Biopsy and Early Liver Metastasis: A Case Report"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5395-662X","authenticated-orcid":false,"given":"Yohei","family":"Tsubouchi","sequence":"first","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7638-6048","authenticated-orcid":false,"given":"Taku","family":"Naiki","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0828-2033","authenticated-orcid":false,"given":"Aya","family":"Naiki\u2010Ito","sequence":"additional","affiliation":[{"name":"Department of Experimental Pathology and Tumor Biology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0584-3712","authenticated-orcid":false,"given":"Rei","family":"Unno","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Etani","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9635-4553","authenticated-orcid":false,"given":"Takashi","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4430-0277","authenticated-orcid":false,"given":"Toshiharu","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7975-2983","authenticated-orcid":false,"given":"Daiki","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-2477","authenticated-orcid":false,"given":"Takahiro","family":"Yasui","sequence":"additional","affiliation":[{"name":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1001\/jama.1942.02830490025006","article-title":"Transurethral Resection of Malignant Lesions of the Prostate Gland","volume":"120","author":"Thompson G. J.","year":"1942","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0022-5347(17)57013-5","article-title":"Squamous Cell Carcinoma of the Prostate: Report of 2 Cases and Review of the Literature","volume":"121","author":"Mott L. J.","year":"1979","journal-title":"Journal of Urology"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","DOI":"10.4081\/rt.2010.e47","article-title":"Clinical Features and Outcomes of 25 Patients With Primary Adenosquamous Cell Carcinoma of the Prostate","volume":"2","author":"Wang J.","year":"2010","journal-title":"Rare Tumors"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12920-021-01068-w","article-title":"Genomic Analysis of Circulating Tumor Cells in Adenosquamous Carcinoma of the Prostate: A Case Report","volume":"14","author":"Kitamura J.","year":"2021","journal-title":"BMC Medical Genomics"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0955"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02105"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol31050178"}],"container-title":["IJU Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.70262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iju5.70262","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.70262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:45:18Z","timestamp":1791182718000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iju5.70262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,4]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/iju5.70262"],"URL":"https:\/\/doi.org\/10.1002\/iju5.70262","archive":["Portico"],"relation":{},"ISSN":["2577-171X","2577-171X"],"issn-type":[{"value":"2577-171X","type":"print"},{"value":"2577-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,4]]},"assertion":[{"value":"2026-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70262"}}