{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:40:51Z","timestamp":1792269651707,"version":"4.4.0"},"reference-count":6,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Belzutifan, a hypoxia\u2010inducible factor 2\u03b1 (HIF\u20102\u03b1) inhibitor, is effective for metastatic renal cell carcinoma (mRCC), although its cardiovascular safety profile remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 52\u2010year\u2010old woman with mRCC developed progressive dyspnea and a 6.7\u2010kg weight gain 27\u2009days after initiating belzutifan as third\u2010line therapy. Chest radiography revealed marked cardiomegaly (cardiothoracic ratio 63.4%), and echocardiography showed preserved left ventricular ejection fraction (67.1%) with mild diastolic dysfunction and findings consistent with congestive heart failure. Intensive diuretic therapy led to rapid improvement, with the cardiothoracic ratio decreasing to 42.7% and NT\u2010proBNP declining from 912 to 203\u2009pg\/mL. After belzutifan rechallenge at a reduced dose, NT\u2010proBNP increased again and subsequently normalized after discontinuation due to disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Belzutifan may be associated with reversible congestive heart failure with preserved ejection fraction. Cardiac evaluation should be considered in patients who develop dyspnea during belzutifan therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70266","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:10:11Z","timestamp":1789049411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Belzutifan\u2010Associated Reversible Heart Failure With Preserved Ejection Fraction in Metastatic Renal Cell Carcinoma"],"prefix":"10.1002","volume":"9","author":[{"given":"Hikaru","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5857-3483","authenticated-orcid":false,"given":"Shigeaki","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0778-1308","authenticated-orcid":false,"given":"Yu","family":"Ishizuya","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1271-3521","authenticated-orcid":false,"given":"Yoshiyuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-1846","authenticated-orcid":false,"given":"Kentaro","family":"Takezawa","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8681-1407","authenticated-orcid":false,"given":"Taigo","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8409-5152","authenticated-orcid":false,"given":"Koji","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5339-4312","authenticated-orcid":false,"given":"Yoichi","family":"Kakuta","sequence":"additional","affiliation":[{"name":"Department of Urology, Graduate School of Medicine The University of Osaka  Osaka 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