{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:55:56Z","timestamp":1790564156997,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Sertoli cell tumors are rare testicular sex cord\u2010stromal tumors, and clinically malignant behavior is uncommon. We report a rapidly progressive metastatic Sertoli cell tumor associated with an\n                      <jats:italic>APC<\/jats:italic>\n                      mutation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>\n                      A 27\u2010year\u2010old man with familial adenomatous polyposis (FAP) presented with painless right scrotal enlargement. Computed tomography revealed a right testicular tumor and multiple pulmonary nodules suspicious for metastases. Right high inguinal orchiectomy was performed. Histopathological and immunohistochemical findings, including nuclear \u03b2\u2010catenin staining, supported Sertoli cell tumor. Despite bleomycin, etoposide, and cisplatin chemotherapy initially achieving stable disease, metastases progressed after three cycles. Comprehensive genomic profiling identified a pathogenic\n                      <jats:italic>APC<\/jats:italic>\n                      variant likely germline due to his FAP; however, no actionable therapeutic target was identified. Widespread systemic metastases developed. The patient died 11\u2009months post\u2010orchiectomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This case highlights the aggressive potential of\n                      <jats:italic>APC<\/jats:italic>\n                      \u2010associated Sertoli cell tumors, characterized by metastatic presentation, limited response to chemotherapy, and a rapidly fatal course.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70274","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:42:01Z","timestamp":1790563321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapidly Progressive Metastatic Sertoli Cell Tumor Associated With an Adenomatous Polyposis Coli Mutation: A Case Report and Literature Review"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0427-0644","authenticated-orcid":false,"given":"Kotaro","family":"Obayashi","sequence":"first","affiliation":[{"name":"Department of Urology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0913-8279","authenticated-orcid":false,"given":"Mika","family":"Terasaki","sequence":"additional","affiliation":[{"name":"Department of Analytic Human Pathology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroya","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5555-5789","authenticated-orcid":false,"given":"Hikaru","family":"Mikami","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3092-1014","authenticated-orcid":false,"given":"Masato","family":"Yanagi","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4556-6601","authenticated-orcid":false,"given":"Hayato","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0787-9321","authenticated-orcid":false,"given":"Yuki","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Toyama","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7053-038X","authenticated-orcid":false,"given":"Ryuji","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Integrated Diagnostic Pathology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2671-7064","authenticated-orcid":false,"given":"Jun","family":"Akatsuka","sequence":"additional","affiliation":[{"name":"Department of Urology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1097\/PAS.0000000000002132","article-title":"Germline APC Alterations May Predispose to Testicular Sex Cord\u2010Stromal Tumors","volume":"47","author":"Siegmund S.","year":"2023","journal-title":"American Journal of Surgical Pathology"},{"key":"e_1_2_12_3_1","first-page":"1707","volume-title":"Campbell\u2010Walsh Urology","author":"Stephenson J. D.","year":"2021"},{"key":"e_1_2_12_4_1","volume-title":"General Rules for Clinical and Pathological Studies on Testicular Tumors","author":"Japanese Urological Association","year":"2026"},{"key":"e_1_2_12_5_1","first-page":"513","article-title":"Classification of Testicular Non\u2010Germ Cell Tumours","volume":"70","author":"Idrees M. T.","year":"2016","journal-title":"Histopathology"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1634\/theoncologist.2019-0692","article-title":"Sertoli Cell Tumors of the Testes: Systematic Literature Review and Meta\u2010Analysis of Outcomes in 435 Patients","volume":"25","author":"Grogg J.","year":"2020","journal-title":"Oncologist"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/00000478-200205000-00001","article-title":"Malignant Sertoli Cell Tumors of the Testis: A Study of 13 Examples of a Neoplasm Frequently Misinterpreted as Seminoma","volume":"26","author":"Henley J. D.","year":"2002","journal-title":"American Journal of Surgical Pathology"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/PAS.0b013e31829cdbc6","article-title":"Frequent Mutation and Nuclear Localization of Beta\u2010Catenin in Sertoli Cell Tumors of the Testis","volume":"38","author":"Perrone F.","year":"2014","journal-title":"American Journal of Surgical Pathology"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/his.15175","article-title":"\u03b2\u2010Catenin Alterations in Testicular Leydig Cell Tumour: An Immunohistochemical and Molecular Analysis","volume":"85","author":"Kitagawa Y.","year":"2024","journal-title":"Histopathology"},{"key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/his.70048","article-title":"Adult Granulosa Cell Tumours of the Testis Analogous to Ovarian Counterparts Are Exceptionally Rare: Analysis of a Multicentric Series and Review of the Literature","volume":"88","author":"Ricci C.","year":"2026","journal-title":"Histopathology"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/00000478-200004000-00007","article-title":"Sex Cord\u2010Stromal Tumors of the Testis With Entrapped Germ Cells: A Lesion Mimicking Unclassified Mixed Germ Cell Sex Cord\u2010Stromal Tumors","volume":"24","author":"Ulbright T. M.","year":"2000","journal-title":"American Journal of Surgical Pathology"},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.pathol.2017.07.013","article-title":"Pitfalls in the Interpretation of Specimens From Patients With Testicular Tumours, With an Emphasis on Variant Morphologies","volume":"50","author":"Ulbright T. M.","year":"2018","journal-title":"Pathology"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1464-410X.1988.tb06598.x","article-title":"Successful Chemotherapy for Disseminated Testicular Sertoli Cell Tumour","volume":"61","author":"Athanassiou A. E.","year":"1988","journal-title":"British Journal of Urology"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00428-012-1332-x","article-title":"Bilateral Sertoli Cell Tumors of the Testis: A Likely New Extracolonic Manifestation of Familial Adenomatous Polyposis","volume":"461","author":"Xiao G. Q.","year":"2012","journal-title":"Virchows Archiv"}],"container-title":["IJU Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.70274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iju5.70274","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.70274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:42:05Z","timestamp":1790563325000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iju5.70274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/iju5.70274"],"URL":"https:\/\/doi.org\/10.1002\/iju5.70274","archive":["Portico"],"relation":{},"ISSN":["2577-171X","2577-171X"],"issn-type":[{"value":"2577-171X","type":"print"},{"value":"2577-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]},"assertion":[{"value":"2026-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70274"}}