{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:39:11Z","timestamp":1792460351556,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>TFE3\u2010rearranged renal cell carcinoma (RCC) is rare, and evidence guiding systemic therapy is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 25\u2010year\u2010old man with gross hematuria had a left renal tumor with hilar lymph node metastasis. Robot\u2010assisted radical nephrectomy and hilar lymph node dissection were performed. Histology, immunohistochemistry, and fluorescence in\u00a0situ hybridization confirmed TFE3\u2010rearranged RCC, pT3aN1. Postoperative pembrolizumab was started because of the high risk of recurrence. Eight months after surgery, lung and retroperitoneal metastases developed. Lenvatinib was added to ongoing pembrolizumab. The metastatic lesions decreased within one month, and a partial response according to Response Evaluation Criteria in Solid Tumors has been maintained for ten months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case suggests that adding a vascular endothelial growth factor receptor tyrosine kinase inhibitor to pembrolizumab may be a therapeutic option for recurrent TFE3\u2010rearranged RCC, although longer follow\u2010up and molecular characterization are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iju5.70280","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:45:27Z","timestamp":1792457127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent\n                    <scp>TFE3<\/scp>\n                    \u2010Rearranged Renal Cell Carcinoma Responding to Pembrolizumab Plus Lenvatinib After Postoperative Pembrolizumab: A Case Report"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2385-008X","authenticated-orcid":false,"given":"Masashi","family":"Fujimoto","sequence":"first","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5665-528X","authenticated-orcid":false,"given":"Tomoyasu","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Urology Nagoya University Graduate School of Medicine  Nagoya Aichi 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