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In the present study, the expression of TRANCE was examined in pre\u2010B\u2004cell lines using flow cytometry and reverse transcription\u2010PCR. Three pre\u2010B\u2004cell lines, 18\u201081, B<jats:sub>3<\/jats:sub>P<jats:sub>8<\/jats:sub>16\u20101, and 38B9, expressed TRANCE on their surface, and two pre\u2010B\u2004cell lines, 70Z\/3 and NFS5, at the late pre\u2010B\u2004cell stage, expressed it at low levels, although their mRNA expression was normal. Another pre\u2010B\u2004cell line, 38\u2010C\u201013, at the intermediate stage between pre\u2010B and immature B\u2004cells, did not express TRANCE. The IL\u20107\u2010dependent pre\u2010B\u2004cell line PreBR, which expresses the pre\u2010B\u2004cell receptor on the cellsurface, also expressed TRANCE. When differentiation of PreBR cells was induced <jats:italic>in vitro<\/jats:italic> by removing IL\u20107 from cultures, TRANCE expression dropped; it was restored by the addition of IL\u20107, suggesting that TRANCE functions in cooperation with IL\u20107. To examine the function of TRANCE, we introduced the TRANCE gene into PreBR cells and established two transfectants that constitutively expressed TRANCE, even in the absence of IL\u20107. In these transfectants, after removal of IL\u20107, the number of cells that succeeded in \u03ba\u2004chain rearrangement was decreased to one third; and CD40 expression decreased to less than one tenth. Moreover, the percentage of cells in the S\/G2\/M phase was increased by 50% over the mock transfectant. These findings indicate that, before \u03ba\u2004chain rearrangement occurs, TRANCE together with IL\u20107 induces pre\u2010B\u2004cells to proliferate and makes this rearrangement more efficient.<\/jats:p>","DOI":"10.1002\/immu.200310007","type":"journal-article","created":{"date-parts":[[2003,2,6]],"date-time":"2003-02-06T01:43:37Z","timestamp":1044495817000},"page":"334-341","source":"Crossref","is-referenced-by-count":9,"title":["TRANCE together with IL\u20107 induces pre\u2010B cells to proliferate"],"prefix":"10.1002","volume":"33","author":[{"given":"Ibuki","family":"Kato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromu","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,1,20]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11089"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.4.537"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/44076"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/36593"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.40.25190"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.12.2075"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3597"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81569-X"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.1.2"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.3.1482"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/16852"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200294797"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/302575a0"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.3.969"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90060-X"},{"key":"e_1_2_7_16_2","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1002\/j.1460-2075.1987.tb02500.x","article-title":"A second gene, VpreB in the \u03bb5\u2004locus of the mouse, which appears to be selectively expressedin pre\u2010B\u2004lymphocytes.","volume":"6","author":"Kudo A.","year":"1987","journal-title":"EMBO J."},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/324579a0"},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/j.1460-2075.1987.tb04725.x","article-title":"Organization of the murine Ig\u2010related \u03bb5\u2004gene transcribed selectively in pre\u2010B lymphocytes.","volume":"6","author":"Kudo A.","year":"1987","journal-title":"EMBO J."},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb02789.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90293-L"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/11.3.453"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.4.435"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.12.6286"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2000.imr017511.x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.17.9360"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117424"},{"key":"e_1_2_7_27_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4049\/jimmunol.161.1.27","article-title":"The role of estrogen receptors and androgen receptors in sex steroid regulation of B\u2004lymphopoiesis.","volume":"161","author":"Smithson G.","year":"1998","journal-title":"J. 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