{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:34:50Z","timestamp":1792722890468,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,1,31]],"date-time":"2003-01-31T00:00:00Z","timestamp":1043971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dendritic cells (DC) that express the type II C\u2010type lectin DC\u2010SIGN (CD209) are located in the submucosa of tissues, where they mediate HIV\u20101 entry. Interestingly, the pathogen\n                    <jats:italic>Candida albicans,<\/jats:italic>\n                    the major cause of hospital\u2010acquired fungal infections, penetrates at similar submucosal sites. Here we demonstrate that DC\u2010SIGN is able to bind\n                    <jats:italic>C.\u2004albicans<\/jats:italic>\n                    both in DC\u2010SIGN\u2010transfected cell lines and in human monocyte\u2010derived DC. The binding was shown to be time\u2010 as well as concentration\u2010dependent, and live as well as heat\u2010inactivated\n                    <jats:italic>C.\u2004albicans<\/jats:italic>\n                    were bound to the same extent. Moreover, in immature DC, DC\u2010SIGN was able to internalize\n                    <jats:italic>C.\u2004albicans<\/jats:italic>\n                    in specific DC\u2010SIGN\u2010enriched vesicles, distinct from those containing the mannose receptor, the other known\n                    <jats:italic>C.\u2004albicans<\/jats:italic>\n                    receptor expressed by DC. Together, these results demonstrate that DC\u2010SIGN is an exquisite pathogen\u2010uptake receptor that captures not only viruses but also fungi.\n                  <\/jats:p>","DOI":"10.1002\/immu.200310029","type":"journal-article","created":{"date-parts":[[2003,2,5]],"date-time":"2003-02-05T20:43:37Z","timestamp":1044477817000},"page":"532-538","source":"Crossref","is-referenced-by-count":325,"title":["The C\u2010type lectin DC\u2010SIGN (CD209) is an antigen\u2010uptake receptor for\n                    <i>Candida albicans<\/i>\n                    on dendritic cells"],"prefix":"10.1002","volume":"33","author":[{"given":"Alessandra","family":"Cambi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlijn","family":"Gijzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Jolanda M.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruurd","family":"Torensma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gosse\u2004J.","family":"Adema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai\u2004G.","family":"Netea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart\u2010Jan","family":"Kullberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigina","family":"Romani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl\u2004G.","family":"Figdor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,1,31]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.09.040191.001415"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199104113241511"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7702654"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408418709104444"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.10.1661"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"6198","DOI":"10.4049\/jimmunol.161.11.6198","article-title":"Interaction of the fungal pathogen Candida albicans with integrin CD11b\/CD18: recognition by the I domain is modulated by the lectin\u2010like domain and the CD18 subunit.","volume":"161","author":"Forsyth C. 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B.","year":"1999","journal-title":"Blood"}],"container-title":["European Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/immu.200310029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T19:16:01Z","timestamp":1700248561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/immu.200310029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1,31]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["10.1002\/immu.200310029"],"URL":"https:\/\/doi.org\/10.1002\/immu.200310029","archive":["Portico"],"relation":{},"ISSN":["0014-2980","1521-4141"],"issn-type":[{"value":"0014-2980","type":"print"},{"value":"1521-4141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1,31]]}}}