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The molecular mechanisms that underlie this phenomenon are not known. In this report we show that expression of \u03b2\u2010catenin in thymocytes enhances thymic involution. The effect of \u03b2\u2010catenin expression is seen in all the thymic sub\u2010populations, suggesting that an age\u2010related developmental process is accelerated. We also show that, as in normal mice, thymic involution does not lead to a drastic reduction in splenic T cells in \u03b2\u2010catenin\u2010transgenic mice. This study identifies \u03b2\u2010catenin expression in thymocytes as a molecular target of age\u2010related thymic involution.<\/jats:p>","DOI":"10.1002\/immu.200390002","type":"journal-article","created":{"date-parts":[[2003,2,19]],"date-time":"2003-02-19T19:15:48Z","timestamp":1045682148000},"page":"12-18","source":"Crossref","is-referenced-by-count":18,"title":["\u03b2\u2010Catenin expression in thymocytes accelerates thymic involution"],"prefix":"10.1002","volume":"33","author":[{"given":"Youyuan","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoti","family":"Sen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,12,13]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(00)01714-X"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006611518223"},{"key":"e_1_2_6_3_2","first-page":"421","article-title":"Involution of the mammalian thymus, one of the leading regulators of aging.","volume":"11","author":"Bodey B.","year":"1997","journal-title":"In vivo"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(86)90043-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(88)90315-2"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830201203"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199806)28:06<1886::AID-IMMU1886>3.0.CO;2-M"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"711","DOI":"10.4049\/jimmunol.162.2.711","article-title":"Maturation of CD4 lymphocytes in the aged microenvironment results in a memory enriched population.","volume":"162","author":"Timm J. 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